Figure 3 shows the SNP-based heritability estimates (on the left) and the phenotypic (above the diagonal) and genetic (below the diagonal) correlations in EUR between the algorithmic case-control diagnosis, and each of the four continuous PTSD symptoms (re-experiencing, avoidance, hyperarousal, and their total; and the genetic correlations for the MVP/PGC case-control meta-analysis). Genetic correlations were consistently high (rg > 0.9) across all PTSD traits, indicating that the traits investigated are all informative with respect to PTSD genetics. The PCL-Total quantitative trait (95%CI SNP-h2 = 0.08–0.10) has significantly higher SNP-based heritability than either the MVP case-control definition (95% CI SNP-h2 = 0.05–0.07, Pdifference = 1.85 × 10−4) or the MVP/PGC case-control meta-analysis (95% CI SNP-h2 = 0.07–0.08, Pdifference = 5.83 × 10−3), and significantly larger SNP-heritability z-score (MVP PCL-total SNP-h2 z = 17.73; MVP case-control SNP-h2 z = 11.62; MVP/PGC SNP-h2 z = 14.80).
