In the EUR sample, we estimated genetic correlations (rg) between the PTSD case-control and the PCL-Total score and health-related traits available from UK Biobank and the PGC (Supplementary Table 8, showing rg for all traits with h2 z-score of 4 or more). The many significant genetic correlations with both PTSD traits include positive rg with major depression, neuroticism, and related symptoms, and negative rg with educational attainment and cognitive performance (Fig. 4). Though the magnitudes of rg observed with PCL-Total and case-control PTSD were highly correlated (Spearman’s rho = 0.970, P = 2.20 × 10−16), ten phenotypes exhibited significantly greater rg with PCL-Total relative to case-control PTSD (Fig. 4a).
