linkage. We used the LOKI software [1,2] to create the matrices after a set of preliminary tests to determine the appropriate number of iterations. However, due to time and computational constraints, we have restricted our attention to chromosome 7. Although the matrices are created irrespective of phenotype, published results from the COGA project have shown linkage with multiple phenotypes on this chromosome [3]. Other members of our group used the matrices to replicate some of these findings [4].
