Sixth, we included few risks that affected three of the leading communicable diseases—HIV/AIDs, tuberculosis, and malaria (beyond deaths in childhood). Overall, we have not included risks for 126 of the 241 most detailed causes included in the GBD, which account for 26·3% of global disease health burden. This shortcoming emphasises the need for a more deliberate research focus to identify and quantify risk factors for the outcomes for which there are presently no risks or few large risks.