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Chunk #57 — ONLINE METHODS — Replication of eQTL signals in independent data sets — Zeller et al. (2010)25

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Genetic variability in the regulation of gene expression in ten regions of the human brain.
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RNA was extracted from monocytes from 1,490 healthy, unrelated German individuals and profiled on Illumina HT12v3 arrays. We downloaded the summary results provided by the authors’ software, which provides all cis-eQTL signals with P <5 × 10−5. The raw expression and genotype data were not publicly available. We removed any signals where the probe failed to be reannotated using ReMOAT (12.1% of signals excluded) or arising from probes containing common polymorphisms (MAF >1%, 10.5% of signals excluded). Results from ~670,000 genotyped SNPs were available for comparison.