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Chunk #56 — ONLINE METHODS — Replication of eQTL signals in independent data sets — North American Brain Expression Consortium (NABEC)

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Genetic variability in the regulation of gene expression in ten regions of the human brain.
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use in eQTL analyses, the expression data were corrected for gender, age, post-mortem interval and batch effects (hybridization batch effects and brain bank) as described previously. We successfully mapped ~40% of the Affymetrix transcript IDs to Illumina probe IDs using good quality sequence similarity matches. The DNA for individuals from NABEC was extracted and analyzed using the Illumina Infinium HumanHap550 v3 chips and subsequently imputed to ~5.3 million markers.