for 48,610 individuals from the EHR. To facilitate mapping to phecodes, ICD-10 codes were back converted to ICD-9 using 2017 general equivalency mapping (GEM). The ICD-10 conversions were combined with the ICD-9 codes to create a dataset with 10,682 unique ICD-9 codes. ICD-9 codes were aggregated to phecodes using the PheWAS R package65 to create 1812 phecodes. Individuals are considered cases for the phenotype if they had at least two instances of the phecode, controls if they had no instance of the phecode, and other/missing if they had one instance or a related phecode. Logistic regression was used to test the association of the PRS with the alcohol-related disorders phecode (phecode number 317) and its sub-phenotype, alcoholism (phecode number 317.1). The analysis was performed in R with PRS as the independent variable and diagnosis as the dependent variable and age, sex, and the first 10 PCs as covariates.
