Diffusion tensors (D) were estimated and FA, MD, AD, and RD maps were calculated based on the estimated tensors in the native space. Group differences in the standardized FA maps were computed using voxelwise two-tailed t-tests with a voxelwise p<0.01 and the cluster size method (Forman et al., 1995) of correction for multiple comparisons. Fifteen FA clusters were found to be significantly different between AUD and control groups. Average FA, AD, and RD values in these clusters were extracted for further ROIs-neuropsychological analyses.
