For full details of image acquisition, processing, and analysis, see supplementary material. Briefly, imaging was performed using a 3.0 Tesla Siemens Tim Trio MRI (Erlangen, Germany). A high-resolution three-dimensional T1-weighted magnetization-prepared rapid gradient-echo (MPRAGE) image with TR=2500 ms, TE=3.5 ms, TI=1200 ms, flip angle=8°, matrix size=256×256×192, and voxel size=1×1×1 mm3; and a turbo spin-echo (TSE) proton-density (PD)-weighted image with TR=7000 ms, TE=11 ms, TI=1200 ms, matrix size=256×256×72, and voxel size=1×1×2 mm3 were acquired. DTI included a double spin-echo echo-planar imaging (EPI) sequence with 37 measurements, 7 at b=0 and 30 at b=1000 s/mm2 with uniformly distributed diffusion-sensitizing gradient directions, TR=9000 ms, TE=91 ms, matrix size=128×128×72, and voxel size=2×2×2 mm3.
