and the use of valuable resources to falsify those erroneous findings. The problem is compounded in whole genome sequencing by the large number of protein-coding genes in the human genome and the many different ways to annotate variants within and around these genes. Despite these concerns, we believe that analysis of whole genome sequence data is not complete until a variety of sensible analyses are attempted and subjected to replication, including detailed study of strong candidate genes as we have argued elsewhere (Vrieze, Iacono, & McGue, 2012).
