We tested 27 million SNPs for association with 17 endophenotypes in a moderately sized study sample. No single variant was significant. Gene-based tests identified four associated genes, and replication is required. The findings suggest that these endophenotypes may not provide sufficient power to discover individual variants or genes relevant to clinical phenomena, at least in a sample of this size using the brute force analytical methods presented here. However, additional analyses are underway and remain to be done, leveraging additional genomic variation, structure, function, and experimental design to test the utility of this sample to detect genetic variants relevant for these endophenotypes.
