For the G×E analyses, we expected that the moderating effect of relationship status would be on a contemporaneous alcohol misuse outcome rather than a cumulative lifetime alcohol misuse outcome, such as ADsx. Accordingly, we used a time-delimited measure of frequency of intoxication for the G×E analyses. Frequency of intoxication was assessed at age 22 by the single item, “How often do you use alcohol in such a way that you get really drunk?” Response options included “never” (0) to “daily” (8). Response categories were transformed to reflect the number of days per month participants were intoxicated and natural log-transformed after adding 1 to adjust for the positive skew and to retain participants who reported “never” (Dick et al., 2001).
