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Chunk #15 — Materials and Method — Measures — Lifetime alcohol dependence symptoms

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Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems.
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The alcohol dependence symptoms (ADsx) measure was the count of the number of lifetime DSM-IV criteria that respondents endorsed from the SSAGA (Bucholz et al., 1994). Responses ranged from 0 to 7. ADsx was natural log-transformed after adding 1 to adjust for the positive skew and to retain participants who endorsed zero symptoms. Individuals who never initiated alcohol use were coded as missing (n = 35).