Multiple groups have developed strategies to identify tissues associated with complex traits 10–14, but few have focused on the identification of salient cell types within a tissue. Furthermore, studies aiming to identify relevant cell types often used only a small number of cell types derived from one or few different brain regions 4,12–18. For example, we recently showed that, among 24 brain cell types, four types of neurons were consistently associated with schizophrenia 12. We were explicit that this conclusion was limited by the relatively few brain regions we studied; other cell types from unsampled regions could conceivably contribute to the disorder.
