Here, we integrate a wider range of gene expression data – tissues across the human body and single-cell gene expression data from an entire nervous system – to identify tissues and cell types underlying a large number of complex traits (Figure 1A,B). We expand on our prior work by showing that additional cell types are associated with schizophrenia. We also find that psychiatric and cognitive traits are generally associated with similar cell types whereas neurological disorders are associated with different cell types. Notably, we show that Parkinson’s disease is associated with cholinergic and monoaminergic neurons (as expected as these include dopaminergic neurons from the substantia nigra), but also with enteric neurons and oligodendrocytes, providing new clues into its etiology.
