Chunk #23 — Results — Kal7 is expressed in the major neuronal cell types in nucleus accumbens and dorsal striatum — Striatal PSDs are enriched in Kal7

Source

Kalrn promoter usage and isoform expression respond to chronic cocaine exposure.

Embedded

yes

Text

Since Rac1 is one of the key substrates of Kal7, its distribution was also monitored (Figure 6). Although attached to the membrane by a geranylgeranyl tail, most of the Rac1 remained associated with the TX-100 washed PSD fraction. Very little Rac1 was removed by the TX-100 extraction step, leaving the TX-100 soluble fraction (TxS) depleted of Rac1.