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Chunk #24 — Results — Kal7 is expressed in the major neuronal cell types in nucleus accumbens and dorsal striatum — Striatal PSDs are enriched in Kal7

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Kalrn promoter usage and isoform expression respond to chronic cocaine exposure.
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We previously quantified the amount of Kal7 in purified PSDs prepared from adult mouse hippocampus and cortex [17]. Using purified ΔKal7 as a standard, the same measurement was made on purified striatal PSDs (Figure 7). The levels of Kal7 in striatal-PSDs were about half of those observed in the cortex and hippocampus. A difference of this magnitude is consistent with the results of in situ hybridization studies of Kalirin expression in these tissues [32].