Chunk #37 — What are the mechanisms by which cannabinoids cause transient psychotic symptoms? — Gamma-aminobutyric acid (GABA)

Source

Cannabis and psychosis/schizophrenia: human studies.

Embedded

yes

Text

Of note, GABAergic deficits have been observed in schizophrenia. Therefore, any reduction of GABA release by cannabinoids in the presence of a preexisting GABA deficit, as might be the case in schizophrenia, may explain why schizophrenia patients show heightened sensitivity to the effects of cannabinoids.