In order to validate our ability to recover known cell types, we assessed the concordance with six previously published and experimentally validated scRNA-seq datasets, comprising two different technologies (Fludigm C1 and 10X Genomics Chromium) and five tissues: cortex (Zeisel et al., 2015), striatum (Muñoz-Manchado et al., 2018), dentate gyrus (Hochgerner et al., 2018), spinal cord (Häring et al., 2018), and sympathetic nervous system (Furlan et al., 2016). Of the 139 previously published clusters, 98% were perfect or near-perfect matches to corresponding clusters in the new compendium (84% perfect, 14% near perfect, 2% mismatches; see Table S2).
