Molecular Architecture of the Mouse Nervous System.

paper Cited Public

Authors: Zeisel, Amit; Hochgerner, Hannah; Lönnerberg, Peter; Johnsson, Anna; Memic, Fatima; van der Zwan, Job; Häring, Martin; Braun, Emelie; Borm, Lars E; La Manno, Gioele; Codeluppi, Simone; Furlan, Alessandro; Lee, Kawai; Skene, Nathan; Harris, Kenneth D; Hjerling-Leffler, Jens; Arenas, Ernest; Ernfors, Patrik; Marklund, Ulrika; Linnarsson, Sten
Year: 2018
Journal: Cell
PMID: 30096314
DOI: 10.1016/j.cell.2018.06.021
PMCID: PMC6086934

Figure 1

Molecular Survey of the Mouse Nervous System Using Single-Cell RNA Sequencing(A) Schematic illustration of the sampling strategy. The brain was divided into coarse anatomical units, and in addition, we sampled from the spinal cord, dorsal root ganglia, sympathetic ganglion, and enteric nervous system.(B) Visualization of the single-cell data using gt-SNE embedding (see STAR Methods). Cells are colored by rank 3 taxonomy units indicated in the legend.(C) Dendrogram describing the taxonomy of all identified cell types. Main branches, corresponding to the taxonomy, are annotated with labels and colored background. The neurotransmitter used by each cell type is indicated below the leaves as colored circles. The lower panel indicates the developmental compartment of origin for each cell types.See also Figure S1 and Tables S1, S2, S3, S4, and S5.

Figure 2

A Map of Neurogenesis in the Juvenile Mouse Brain(A) A cut-out from dendrogram of relevant cell types, including neuroblasts, radial glia-like cells, astrocytes, OPCs, and ependymal cells.(B) Sketch illustrating the locations where we found neurogenic activity.(C) gt-SNE embedding of all cells from the relevant cell types shown in (A). The dashed line suggests the border between glia-like cells and neuroblasts.(D) Expression distribution of individual key genes projected onto the gt-SNE embedding.See also Figure S2.

Figure 3

Molecular and Spatial Diversity of the Astroependymal Cells in the CNS(A) Subtree describing the hierarchy of astroependymal cell types.(B) Schematic sagittal section showing the location of astroependymal cells.(C–E) gt-SNE embedding of all cells from the relevant clusters colored by cluster identity (C), tissue of origin (D), and patterning transcription factors (E).(F) Validation of spatial distribution of astrocytes cell types using multiplex ISH (RNAscope). Images from three consecutive sections were aligned and overlaid (see STAR Methods) to generate a composite with dots representing cells (upper panel). Below, high-magnification images show details of spatial location. Scale bars: top and bottom left, 500 μm; right, 1000 μm (cerebellum overview) and 100μm (olfactory bulb and cerebellum zoom-ins).(G) Gene expression of selected markers shown on the gt-SNE layout.

Figure 4

Convergence to a Common State at the Early Stages of Oligodendrocytes Lineage(A and B) gt-SNE embedding of the three first stages of the oligodendrocytes lineage OPC, COP, and NFOL colored by cluster identity (A) and tissue of origin (B). Edges in (A) connect nodes between mutual neighbors (k = 150), but only if they are from different clusters.(C) Gene expression of selected markers overlaid on gt-SNE embedding.(D) Patterning transcription factor analysis. Circles represent fraction of positive cells in each cluster and brain region.(E) Illustration of the proposed model of primary patterning, loss of regional identity and secondary diversification.

Figure 5

Diversity of the Vasculature and Neural-Crest-like Glia(A) Subtree describing the vasculature and neural-crest-like glia.(B) Expression dot plots for marker genes on log scale and jittered vertically in a uniform interval. Dots are colored only if the trinarization score is positive (posterior probability greater than 0.95), and colors represent the taxonomy rank 4 taxa.(C) The tissue contribution to each cluster represented by the circle size (enteric glia not shown).(D) Schematic illustration of the approximate position of vascular cell types and the meninges.See also Figure S3.

Figure 6

Neuronal Cell Types Are Spatially RestrictedExamples of inferred spatial distributions for cell types across the brain. The left column shows reference images from the Allen Brain Atlas. Each row shows one coronal section, ordered rostrocaudally, and each column shows one cluster as indicated at the top. For every cluster and every voxel, the correlation coefficient is depicted by the colormap (dark high, white low). Labels indicate the top-scoring anatomical unit for each cluster.See also Figure S5.

Figure 7

Drivers of Cellular Diversity(A) Gene ontology analysis of the most highly enriched genes in CNS neuronal clusters. Each panel shows the significantly (false discovery rate [FDR] < 10%) enriched terms ranked by FDR. Bars show the percentage of all genes (belonging to each term) that were enriched and the FDR. Colors indicate major categories of terms, as indicated below the figure.(B) Gene expression of developmental patterning transcription factors is shown along the cell-type taxonomy. Each row represents one transcription factor, and columns represent clusters. Circles represent mean expression values proportional to area. Genes are sorted according to their expression pattern, with Hox genes sorted rostrocaudally. Labels on the right indicate the approximate anatomical extent of the expression of corresponding Hox genes.See also Figures S4, S6, and S7.

Figure S1

Data Quality, Related to Figure 1(A) Number of cells retained in analysis for each level of the pipeline.(B) Circle plots showing number of cells from each main class and each dissection region.(C) Cluster robustness and relatedness. The heatmap illustrates the performance of a random forest classifier, showing the average probability assigned to every cell type (rows) for each test cell of given type (columns). When the correct cell type (diagonal) has high probability, almost every test cell will be correctly classified.(D,E) Magnified view of heatmap as indicated in (C).(F) Distribution of Gene and UMI counts for individual Chromium samples (gray) and major cell classes (colored), shown for each of a representative selection of tissues.(G) Comparison of cell type fractions observed by osmFISH (single-molecule fluorescent in situ hybridization) and scRNA-seq.(H) Comparison of oligodendrocyte lineage clustering in the present paper and those previously published in Marques et al., 2016.

Figure S2

Markers and Validation of Neurogenesis and Astroependymal Cells, Related to Figure 2(A) Additional marker genes for neurogenesis-related clusters, relevant clusters are indicated on the g-tSNE embedding.(B) Additional marker genes for various astroependymal cell types. The most enriched cluster is indicated.(C) Additional close-ups from validation using RNAscope. Genes and location indicated around the image. Scale bars: 500μm (CB, SVZ); 100μm (OB).(D) Composite image with colored dots representing cells, reconstructed from Allen Brain Atlas images, similar to Figure 3F but showing in situ hybridization.(E,F) Position of reference points used for alignment of multiple sagittal sections of RNAscope (E) and Allen Brain in situ hybridization (F) images.(G) In situ hybridization (Allen Brain Atlas) showing the extent of expression of Slc17a6 and Slc17a7, for comparison with astrocyte cell types.

Figure S3

Markers of Neural-Crest-like Glia and Vascular Cell Types, Related to Figure 5(A) Additional marker genes for the neural crest-like glia taxonomy unit, related to Figure 5. First panel on the left show the different clusters. Other panels show the expression (red high) distribution of marker genes. Black arrows indicate small clusters.(B) Similar to (A) but for the vasculature taxon.(C) Scatterplot showing differences between Schwann cells and mature oligodendrocytes (MOL) clusters.Values shown are log2(x+1) transformed average molecule counts. The top 10 differentially expressed genes are shown in red and labeled.

Figure S4

Neurons of the Peripheral Nervous System, Related to Figure 7(A) Hierarchical structure of the peripheral nervous system neuronal cell types. Neurotransmitters used by each cell types are indicated by the colored dots next to each leaf.(B) gt-SNE embedding of all related cells demonstrate the diversity and abundance of the different clusters.(C) Dot plots for marker genes along the PNS neurons. Dots show gene expression on log scale, and jittered vertically for clarity. Colors are shown only if the trinarization score is positive (posterior probability greater than 0.95 with f = 0.2).

Figure S5

Spatial Distribution of All Telencephalon Excitatory Projecting Neurons, Related to Figure 6Dendrogram above shows the hierarchical structure as in Figure 1C. Left, reference atlas annotation (Allen Brain Atlas). Each column shows the expression map of an individual cluster, where dark brown is high and white is low correlation.

Figure S6

Neurotransmitter Modularity, Related to Figure 7(A) Co-expression of neurotransmitters. Rows and columns represent neurotransmitters. Circle size represents the number of cells in clusters with the indicated combination. Each circle shows (as a pie chart) the brain compartment in which we found the relevant clusters.(B) Analysis of pan-markers along the different ranks of the taxonomy. The heatmap represents the percentage of clusters with trinarization score greater than 90% within the taxonomy unit. Rows represent taxonomy units and columns genes.(C) Similar co-expression analysis as in (A) but with individual genes encoding neurotransmitters and neuropeptides. Upper half of the matrix shows pie charts representing only the compartment distribution. Lower part of the matrix represent the frequency each combination was found.(D) Summary diagram of the biosynthesis components and transporters used to define neurotransmitter phenotypes. Asterisks indicate the genes used separately (glutamatergic neurons) or jointly (all other) to identify each class of neurotransmitter.

Figure S7

Expression Patterns of Transcription Factors, Related to Figure 7Each section shows the expression of the indicated family of transcription factors, omitting genes that showed uniform or no expression. Circle areas are shown proportional to average gene expression in each cluster, normalized by row.

#	Section	Preview
0	Introduction	The organization of the adult mammalian nervous system is the result of developmental, functional,…
1	Introduction	The question therefore arises as to whether the molecular identity of a cell is determined mainly by…
2	Introduction	Pioneering work has revealed the broad patterns of gene expression across the mammalian brain (Lein…
3	Results — A Molecular Survey of the Mouse Nervous System	We performed a comprehensive survey of the adolescent mouse nervous system by scRNA-seq. We…
4	Results — A Molecular Survey of the Mouse Nervous System	We sampled cells without selection, except in the intestine, where we isolated neural-crest-derived…
5	Results — A Molecular Survey of the Mouse Nervous System	Preliminary analyses showed that the dataset contained hundreds of distinct cell types and that the…
6	Results — A Molecular Survey of the Mouse Nervous System	After an initial quality assessment of samples and cells, we retained 492,949 cells as inputs to the…
7	Results — A Molecular Survey of the Mouse Nervous System	To assess the robustness of the clusters, we trained a random forest classifier to recognize cluster…
8	Results — A Molecular Survey of the Mouse Nervous System	In order to validate our ability to recover known cell types, we assessed the concordance with six…
9	Results — A Molecular Survey of the Mouse Nervous System	We performed a comprehensive annotation of the clusters using a variety of automated and manual…
10	Results — A Molecular Survey of the Mouse Nervous System	We trained a support-vector machine classifier to automatically assign each cell to one of seven…
11	Results — A Molecular Survey of the Mouse Nervous System	To begin to understand the molecular organization of the mammalian nervous system, we calculated a…
12	Results — A Molecular Survey of the Mouse Nervous System	At the top level, neurons were separated from non-neuronal types regardless of tissue, reflecting a…
13	Results — A Molecular Survey of the Mouse Nervous System	PNS neurons segregated from the CNS, reflecting the developmental split between neural-crest-derived…
14	Results — Postnatal Neurogenesis in the Central Nervous System	Although most neuronal types were already mature at the age investigated (postnatal days 20–30),…
15	Results — Postnatal Neurogenesis in the Central Nervous System	Neuroblasts across the brain fell into two general categories represented by two subtrees in the…
16	Results — Astroependymal Cells Are Diverse and Spatially Patterned	Astrocytes, ependymal cells, and radial glia are developmentally related cell types and formed a…
17	Results — Astroependymal Cells Are Diverse and Spatially Patterned	Three types of ependymal cells all expressed Foxj1, the master regulator of motile cilia (Yu et al.,…
18	Results — Astroependymal Cells Are Diverse and Spatially Patterned	Astrocytes were first described in 1858 by Rudolf Virchow, and in the second half of the 19th…
19	Results — Astroependymal Cells Are Diverse and Spatially Patterned	Here, we observed seven molecularly distinct types of astrocytes with clear regionally specialized…

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Activational and organizational actions of gonadal hormones on the sexual dimorphism of the α<sub>6</sub>-subunit containing GABA<sub>A</sub> receptor in Wistar rats with neuropathic pain.	Pizaña-Encarnación JM et al.	—	2025	→
Adrenergic Control of P2Y6 Receptor-Dependent Phagocytosis in Rodent and Human Microglia.	Deluc T et al.	—	2025	→
Advances and applications in single-cell and spatial genomics.	Wang J et al.	—	2025	→
An AAV capsid proposed as microglia-targeting directs genetic expression in forebrain excitatory neurons.	Cao W et al.	—	2025	→
A neuronal architecture underlying autonomic dysreflexia.	Soriano JE et al.	—	2025	→
Anxiety-like behavior and altered hippocampal activity in a transgenic mouse model of Fabry disease.	Kummer K et al.	—	2025	→
APOE4 to APOE2 allelic switching in mice improves Alzheimer's disease-related metabolic signatures, neuropathology and cognition.	Golden LR et al.	—	2025	→
A postsynaptic GPR158-PLCXD2 complex controls spine apparatus abundance and dendritic spine maturation.	Verpoort B et al.	—	2025	→
Are we there yet? Exploring astrocyte heterogeneity one cell at a time.	O'Dea MR et al.	—	2025	→
A role for fibroblast and mural cell subsets in a nerve ligation model of neuropathic pain?	Villa-Hernandez S et al.	—	2025	→
A role for leucine-rich, glioma inactivated 1 in regulating pain sensitivity.	Farah A et al.	—	2025	→
Aromatase and its role in shaping sex-differentiated brain networks.	Bourdon NS et al.	—	2025	→
Artemin sensitises mouse (Mus musculus) and naked mole-rat (Heterocephalus glaber) sensory neurons in vitro.	Qiu L et al.	—	2025	→
A Single-Nucleus Transcriptomic Atlas of the Mouse Lumbar Spinal Cord: Functional Implications of Non-Coding RNAs.	Ruiz-Amezcua P et al.	—	2025	→
A Sox2 enhancer cluster regulates region-specific neural fates from mouse embryonic stem cells.	Tobias IC et al.	—	2025	→
A spatial atlas of the complement system uncovers unique expression patterns in postnatal brain development in mice.	Zhang Y et al.	—	2025	→
Association and shared biological bases between birth weight and cortical structure.	Zhang L et al.	—	2025	→
Astrocyte alterations during Osmotic Demyelination Syndrome: intermediate filaments, aggresomes, proteasomes, and glycogen storages.	Gilloteaux J et al.	—	2025	→
Astrocyte diversity and subtypes: aligning transcriptomics with multimodal perspectives.	Hennes M et al.	—	2025	→
Astrocyte heterogeneity in ischemic stroke: Molecular mechanisms and therapeutic targets.	Li D et al.	—	2025	→
Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter.	Bocchi R et al.	—	2025	→
Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number.	Qin L et al.	—	2025	→
Astrocytopathy Is Associated with CA1 Synaptic Dysfunction in a Mouse Model of Down Syndrome.	Fernández-Blanco Á et al.	—	2025	→
ATP Metabolism of Astrocytes: Consumption, Regeneration and Restoration.	Dringen R et al.	—	2025	→
A transcriptional atlas of gut-innervating neurons reveals activation of interferon signaling and ferroptosis during intestinal inflammation.	Forster PM et al.	—	2025	→
A transcriptomic atlas of astrocyte heterogeneity across space and time in mouse and marmoset.	Schroeder ME et al.	—	2025	→
Behavioural, immunological and transcriptomic consequences of post-weaning social isolation and chronic celecoxib administration in mouse.	Laighneach A et al.	—	2025	→
Beyond vessels: unraveling the impact of VEGFs on neuronal functions and structure.	Aksan B et al.	—	2025	→
Bi-directional communication between intrinsic enteric neurons and ILC2s inhibits host defense against helminth infection.	Wang Y et al.	—	2025	→
Biomechanical control of vascular morphogenesis by the surrounding stiffness.	Hanada Y et al.	—	2025	→
Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke.	Bernier LP et al.	—	2025	→
C1ql1 expression in oligodendrocyte progenitor cells promotes oligodendrocyte differentiation.	Altunay ZM et al.	—	2025	→
Calcium transport across intestinal epithelia depends on voltage-gated sodium channels and endocannabinoid system.	Thammayon N et al.	—	2025	→
CellMemory: hierarchical interpretation of out-of-distribution cells using bottlenecked transformer.	Wang Q et al.	—	2025	→
Cell-Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory.	Li L et al.	—	2025	→
Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development.	Yim KM et al.	—	2025	→
Central FGF19 signaling enhances energy homeostasis and adipose tissue thermogenesis through sympathetic activation in obese mice.	Zangerolamo L et al.	—	2025	→
Characterization of single neurons reprogrammed by pancreatic cancer.	Thiel V et al.	—	2025	→
Chromatin accessibility during human first-trimester neurodevelopment.	Mannens CCA et al.	—	2025	→
Chronic integrated stress response causes dysregulated cholesterol synthesis in white matter disease.	Lin K et al.	—	2025	→
Clonal Tracking in the Mouse Brain with Single-Cell RNA-Seq.	Ratz M et al.	—	2025	→
Cochlear Cell Atlas of Two Laryngeal Echolocating Bats-New Evidence for the Adaptive Nervous Physiology in Constant Frequency Bat.	Wang X et al.	—	2025	→
Combined statistical-biophysical modeling links ion channel genes to physiology of cortical neuron types.	Bernaerts Y et al.	—	2025	→
Context Specificity of MAP3K DLK Signaling in the Nervous System: Insights from Genetics and Genomics.	Ritchie EM et al.	—	2025	→
Cortical arealization of interneurons defines shared and distinct molecular programs in developing human and macaque brains.	Feng X et al.	—	2025	→
Decoding Alzheimer's Disease: Single-Cell Sequencing Uncovers Brain Cell Heterogeneity and Pathogenesis.	Ma YN et al.	—	2025	→
Decoding dengue's neurological assault: insights from single-cell CNS analysis in an immunocompromised mouse model.	Qiu M et al.	—	2025	→
Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia.	Grundtner S et al.	—	2025	→
Demyelination-related pain: role of lysophosphatidic acid in satellite glial cell-neuron crosstalk.	Wang Y et al.	—	2025	→
Design of antinociceptive peptide by grafting domains between scorpion β-neurotoxins.	Montero-Dominguez PA et al.	—	2025	→
Detection of Mitotic Neuroblasts Provides Additional Evidence of Steady-State Neurogenesis in the Adult Small Intestinal Myenteric Plexus.	Gorecki AM et al.	—	2025	→
Developmental maturation and regional heterogeneity but no sexual dimorphism of the murine CNS myelin proteome.	Siems SB et al.	—	2025	→
Developmental regulation of long-range neuroblast migration by Eph/ephrin signaling.	Yeroshenko D et al.	—	2025	→
Diminished angiogenic capacity in the hippocampus compared to the cortex indicates regional vulnerability.	Li X et al.	—	2025	→
Direct and bisulfite-free 5-methylcytosine and 5-hydroxymethylcytosine sequencing at single-cell resolution with scTAPS and scCAPS + .	Chen X et al.	—	2025	→
Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomics.	Burns MS et al.	—	2025	→
Divergence in neuronal signaling pathways despite conserved neuronal identity among Caenorhabditis species.	Toker IA et al.	—	2025	→
Divergent combinations of enhancers encode spatial gene expression.	Hong D et al.	—	2025	→
Downregulation of STAT3 transcription factor reverses synaptotoxic phenotype of reactive astrocytes associated with prion diseases.	Kushwaha R et al.	—	2025	→
Dual role of FOXG1 in regulating gliogenesis in the developing neocortex via the FGF signalling pathway.	Bose M et al.	—	2025	→
Dysregulated synaptic gene expression in oligodendrocytes of spinal and bulbar muscular atrophy.	Iida M et al.	—	2025	→
Effect of Corticosterone on Gene Expression in the Context of Global Hippocampal Transcription.	Juszczak GR et al.	—	2025	→
Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder.	Song BJ et al.	—	2025	→
Elucidation and application of the neuroimmune axis between depression and autoimmune diseases: A genome wide and cohort study.	Sun F et al.	—	2025	→
Emerging evidence of artemin/GFRα3 signaling in musculoskeletal pain.	Gupta A et al.	—	2025	→
Entangled cellular and molecular relationships at the sensory neuron-cancer interface.	Sur D et al.	—	2025	→
Enteric Glia.	Rao M et al.	—	2025	→
Enteric glutamatergic interneurons regulate intestinal motility.	Hamnett R et al.	—	2025	→
Enteric nervous system-derived VIP restrains differentiation of LGR5<sup>+</sup> stem cells toward the secretory lineage impeding type 2 immune programs.	Jakob MO et al.	—	2025	→
Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force.	Xie Z et al.	—	2025	→
ESC models of autism with copy-number variations reveal cell-type-specific translational vulnerability.	Nomura J et al.	—	2025	→
Established and emerging roles of protein kinases in regulating primary sensory neurons in injury-and inflammation-associated pain.	Zimmermann D et al.	—	2025	→
Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line.	von Mücke-Heim IA et al.	—	2025	→
Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain.	Lee CJ et al.	—	2025	→
Fate plasticity of interneuron specification.	Mostajo-Radji MA et al.	—	2025	→
Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.	Khoury N et al.	—	2025	→
Flexible analysis of spatial transcriptomics data (FAST): a deconvolution approach.	Zhang M et al.	—	2025	→
From identity to function: unveiling the cellular complexity of hypothalamic feeding circuits.	Littleton SH et al.	—	2025	→
Functional and molecular insights into muscle proprioceptors.	Lallemend F et al.	—	2025	→
Future projections for mammalian whole-brain simulations based on technological trends in related fields.	Igarashi J	—	2025	→
Genetic targeting of myelinated primary afferent neurons using a new Nefh<sup>CreERT2</sup> knock-in mouse.	Chen JC et al.	—	2025	→
Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder.	Strom NI et al.	—	2025	→
Genomic stress in diseases stemming from defects in the second brain.	Mombeek LMM et al.	—	2025	→
Genomics yields biological and phenotypic insights into bipolar disorder.	O'Connell KS et al.	—	2025	→
Glutamatergic and GABAergic Synapses in the Human Spinal Dorsal Horn Revealed With Immunohistochemistry.	Davis OC et al.	—	2025	→
GPR37L1 identifies spinal cord astrocytes and protects neuropathic pain after nerve injury.	Xu J et al.	—	2025	→
Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis.	Robertson K et al.	—	2025	→
Gustatory-neuron-supplied R-spondin-2 is required for taste bud replenishment.	Xu J et al.	—	2025	→
Gut sensory neurons as regulators of neuro-immune-microbial interactions: from molecular mechanisms to precision therapy for IBD/IBS.	Sun N et al.	—	2025	→
Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours.	Luskin AT et al.	—	2025	→
High-Fidelity Transcriptome Reconstruction of Degraded RNA-Seq Samples Using Denoising Diffusion Models.	Xiao K et al.	—	2025	→
High order expression dependencies finely resolve cryptic states and subtypes in single cell data.	Jansma A et al.	—	2025	→
High-precision cell-type mapping and annotation of single-cell spatial transcriptomics with STAMapper.	Shen Q et al.	—	2025	→
Human neuron subtype programming via single-cell transcriptome-coupled patterning screens.	Lin HC et al.	—	2025	→
Hypomyelination in autism-associated neuroligin-3 mutant mice impairs parvalbumin interneuron excitability, gamma oscillations, and sensory discrimination.	He Y et al.	—	2025	→
Identification of the velum interpositum as a meningeal-CNS route for myeloid cell trafficking into the brain.	Hohsfield LA et al.	—	2025	→
Immune checkpoint TIM-3 regulates microglia and Alzheimer's disease.	Kimura K et al.	—	2025	→
Immune control of brain physiology.	Kovacs M et al.	—	2025	→
Impaired touch sensation on hairy skin in HCN3-deficient mice.	Metzner K et al.	—	2025	→
Inhibition of FAM19A5 reverses synaptic loss and cognitive decline in mouse models of Alzheimer's disease.	Kim HB et al.	—	2025	→
Inhibition of Phosphodiesterase 10A Alleviates Pain-like Behavior in Mice.	Gross T et al.	—	2025	→
Interleukin-12 signaling drives Alzheimer's disease pathology through disrupting neuronal and oligodendrocyte homeostasis.	Schneeberger S et al.	—	2025	→
Interpretable niche-based cell‒cell communication inference using multi-view graph neural networks.	Qi J et al.	—	2025	→
Investigating Mechanically Activated Currents from Trigeminal Neurons of Nonhuman Primates.	Lindquist KA et al.	—	2025	→
In vitro derivation of midbrain dopaminergic neurons from porcine embryonic stem cells in multi-dimensional conditions.	Choi H et al.	—	2025	→
Large-scale exome sequencing identified 18 novel genes for neuroticism in 394,005 UK-based individuals.	Wu XR et al.	—	2025	→
Late development of OCD-like phenotypes in Dlgap1 knockout mice.	Minagawa K et al.	—	2025	→
<i>Spp1</i> Appears to Be a Key Gene for Sporadic Obstructive Hydrocephalus in the Absence of AQP4.	Echevarría M et al.	—	2025	→
Management of Gastrointestinal Symptoms in Parkinson's Disease.	Chiang HL et al.	—	2025	→
Mapping the cellular etiology of schizophrenia and complex brain phenotypes.	Duncan LE et al.	—	2025	→
MDFIC2 is a PIEZO channel modulator that can alleviate mechanical allodynia associated with neuropathic pain.	Habib AM et al.	—	2025	→
Meta-Analysis of Gene Expression in Bulk-Processed Post-Mortem Spinal Cord from ALS Patients and Normal Controls.	Swindell WR	—	2025	→
Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus.	Perzel Mandell KA et al.	—	2025	→
Metabolic stress and age drive inflammation and cognitive decline in mice and humans.	Elzinga SE et al.	—	2025	→
Microglial cyclooxygenase-1 modulates cerebral capillary basal tone in vivo in mice.	Mills WA et al.	—	2025	→
Microglia-neuron crosstalk through Hex-GM2-MGL2 maintains brain homeostasis.	Frosch M et al.	—	2025	→
Micro-scale control of oligodendrocyte morphology and myelination by the intellectual disability-linked protein acyltransferase ZDHHC9.	Jeong HK et al.	—	2025	→
Mitogen- and stress-activated kinase 1 in primary sensory neurons contributes to formalin-induced tonic pain.	Irfan J et al.	—	2025	→
Molecular and cellular characteristics of cerebrovascular cell types and their contribution to neurodegenerative diseases.	Garcia FJ et al.	—	2025	→
Molecular and functional diversity of the autonomic nervous system.	Wang T et al.	—	2025	→
Molecular profiling of adult C. elegans glia across sexes by single-nuclear RNA-seq.	Purice MD et al.	—	2025	→
Morphological evidence suggestive of a hierarchical mode of glial cell diversification and intrinsic developmental plasticity within the murine enteric nervous system.	Lefèvre MA et al.	—	2025	→
Multiplexed spatial mapping of chromatin features, transcriptome and proteins in tissues.	Guo P et al.	—	2025	→
Na<sup>+</sup>/K<sup>+</sup>-ATPase Modulates Purinergic P2X3 Receptor Function to Drive Bone Cancer Pain.	Huang S et al.	—	2025	→
Na V 1.8/Na V 1.9 double deletion mildly affects acute pain responses in mice.	Alves-Simões M et al.	—	2025	→
NDRG1 and its family members: More than just metastasis suppressor proteins and targets of thiosemicarbazones.	Azad MG et al.	—	2025	→
Neural-activity-regulated and glia-mediated control of brain lymphatic development.	Li J et al.	—	2025	→
Neurogenic inflammation and itch in barrier tissues.	Liu R et al.	—	2025	→
Neuroglia in hepatic encephalopathy.	Zielińska M et al.	—	2025	→
Neuroimmune Circuits in Allergic Diseases.	Han C et al.	—	2025	→
Neuroinflammation in an Optimized Model of Lysophosphatidic Acid (LPA)-Induced Post-hemorrhagic Hydrocephalus.	Sánchez-Pavón P et al.	—	2025	→
Neuron-specific homologous coding genes and non-coding regulatory regions are the most conserved amongst amniotes despite neuron-specific cell size diversity.	Xu L et al.	—	2025	→
Neurons throughout the brain embed robust signatures of their anatomical location into spike trains.	Tolossa GB et al.	—	2025	→
Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development.	Ries C et al.	—	2025	→
Neuropharmacology and physiology of human dorsal root ganglion neurons responsible for nociception: state-of-the-art and future directions.	O'Brien JA et al.	—	2025	→
Neurotoxins Acting on TRPV1-Building a Molecular Template for the Study of Pain and Thermal Dysfunctions.	Beignon F et al.	—	2025	→
Next-generation enteric neuroscience - fostering the future of the field.	Muppirala AN et al.	—	2025	→
NKG2D receptor ligands are cell surface biomarkers for injured murine and human nociceptive sensory neurons.	Wang S et al.	—	2025	→
Notch signaling blockade links transcriptome heterogeneity in quiescent neural stem cells with reactivation routes and potential.	Morizet D et al.	—	2025	→
Not Just Neurons: Pain Is Orchestrated in Partnership with Many Non-neuronal Cells.	Smith ESJ et al.	—	2025	→
Oligodendrocyte Slc48a1 (Hrg1) encodes a functional heme transporter required for myelin integrity.	Stockley JH et al.	—	2025	→
Opioid-driven disruption of the septum reveals a role for neurotensin-expressing neurons in withdrawal.	Simon RC et al.	—	2025	→
Optimizing Xenium In Situ data utility by quality assessment and best-practice analysis workflows.	Marco Salas S et al.	—	2025	→
Optogenetics-integrated gut organ culture system connects enteric neurons dynamics and gut homeostasis.	Naim G et al.	—	2025	→
Orchestrating the neuroglial compartment: Ontogeny and developmental interaction of astrocytes, oligodendrocytes, and microglia.	Schuurmans IME et al.	—	2025	→
Pain persists in mice lacking both Substance P and CGRPα signaling.	MacDonald DI et al.	—	2025	→
Partial FAM19A5 deficiency in mice leads to disrupted spine maturation, hyperactivity, and an altered fear response.	Shahapal A et al.	—	2025	→
PDE10A as a novel diagnostic and therapeutic target in cancer: insights and challenges.	Ghoflchi S et al.	—	2025	→
Pericytes in the brain and heart: functional roles and response to ischaemia and reperfusion.	Dalkara T et al.	—	2025	→
Persistent changes in the dorsal root ganglion nociceptor translatome governs hyperalgesic priming in mice: roles of GPR88 and Meteorin.	Sankaranarayanan I et al.	—	2025	→
Pharmacological potential of endocannabinoid and endocannabinoid-like compounds in protecting intestinal structure and metabolism under high-fat conditions.	Vari F et al.	—	2025	→
Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function.	Al-Hosni R et al.	—	2025	→
Polyvagal theory: a journey from physiological observation to neural innervation and clinical insight.	Porges SW	—	2025	→
Probing Cell-Type Specificity of Mutant Phenotype at Transcriptomic Level Using Mosaic Analysis with Double Markers (MADM).	Cheung G et al.	—	2025	→
Protease-activated receptor 1-mediated matrix metalloprotease signaling in sensory neurons.	Williams KJ et al.	—	2025	→
Protocol to study neuronal membrane proteasome function in mouse peripheral sensory neurons.	Krueger ER et al.	—	2025	→
Psychedelic control of neuroimmune interactions governing fear.	Chung EN et al.	—	2025	→
Purinergic P2Y<sub>1</sub> and P2Y<sub>12</sub> receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk.	Hendler BJ et al.	—	2025	→
Reactive Microglia and Astrocytes as Therapeutic Targets in Prion Diseases.	Makarava N et al.	—	2025	→
Redox-dependent activation of protein kinase G1α contributes to transient receptor potential cation channel subfamily V member 1-mediated acute nociceptive pain behavior.	Berg T et al.	—	2025	→
Research advances in structure and functions of complement C1q/tumor necrosis factor-related protein 4: A review.	Liang C et al.	—	2025	→
Resolving forebrain developmental organisation by analysis of differential growth patterns.	Manning E et al.	—	2025	→
Response to comments by Kong et al.	Kwak H et al.	—	2025	→
Revealing the Best Strategies for Rare Cell Type Detection in Multi-Sample Single-Cell Datasets.	Ye Z et al.	—	2025	→
Rewiring the Brain Through the Gut: Insights into Microbiota-Nervous System Interactions.	Savulescu-Fiedler I et al.	—	2025	→
Scalable spatial single-cell transcriptomics and translatomics in 3D thick tissue blocks.	Sui X et al.	—	2025	→
scMODAL: a general deep learning framework for comprehensive single-cell multi-omics data alignment with feature links.	Wang G et al.	—	2025	→
Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation.	Liu AW et al.	—	2025	→
Searching for the cellular underpinnings of the selective vulnerability to tauopathic insults in Alzheimer's disease.	Torok J et al.	—	2025	→
Secreted neurofilament light chain after neuronal damage induces myeloid cell activation and neuroinflammation.	Kahn OI et al.	—	2025	→
Shared genetic architecture and bidirectional clinical risks within the psycho-metabolic nexus.	Guo X et al.	—	2025	→
Single-cell chromatin accessibility landscape profiling reveals the diversity of epigenetic regulation in the rat nervous system.	Ma P et al.	—	2025	→
Single-cell genomics meets systems neuroscience: Insights from mapping the brain circuitry of stress.	Hanchate NK	—	2025	→
Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity.	Xu Y et al.	—	2025	→
Single-cell parallel analysis of DNA damage and transcriptome reveals selective genome vulnerability.	Bai D et al.	—	2025	→
Single Cell Profiling in the Sox10<sup>Dom</sup> Hirschsprung Mouse Implicates Hox Genes in Enteric Neuron Trajectory Allocation.	Avila JA et al.	—	2025	→
Single-cell RNA sequencing of adult primate neocortex reveals the regulatory dynamics of neural plasticity.	Zhang C et al.	—	2025	→
Single-cell spatial transcriptomic atlas of the whole mouse brain.	Han L et al.	—	2025	→
Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2<sup>R47H</sup> Alzheimer's risk gene mutation.	Johnston KG et al.	—	2025	→
Single-cell stemness analysis highlights Midkine-LRP1 pathway and identifies new bladder cancer subtypes.	Qian C et al.	—	2025	→
Single-cell technology for cell-based drug delivery and pharmaceutical research.	Hu H et al.	—	2025	→
Single-cell transcriptome analyses of PBMCs reveal the immunological characteristics of individuals with phlegm-dampness constitution.	Zhao W et al.	—	2025	→
Single-nuclei RNA-sequencing fails to detect molecular dysregulation in the preeclamptic placenta.	Admati I et al.	—	2025	→
Single nucleus RNA sequencing of the cerebral cortex from genetically diverse inbred mouse strains reveals differences in pericyte and endothelial cell composition.	Park J et al.	—	2025	→
Single-nucleus RNA sequencing reveals a preclinical model for the most common subtype of glioblastoma.	García-Vicente L et al.	—	2025	→
Single-nucleus transcriptome atlas of the basal forebrain reveals diverse ageing-related pathways.	Chen J et al.	—	2025	→
Single-nucleus transcriptomic profiling reveals temporal dynamics of neuroinflammation and myelin repair after intracerebral haemorrhage.	Chen Z et al.	—	2025	→
Slack potassium channels in spinal dorsal horn neurons control neuropathic pain and acute itch.	Zhou F et al.	—	2025	→
SLC45A4 is a pain gene encoding a neuronal polyamine transporter.	Middleton SJ et al.	—	2025	→
Sparse deconvolution of cell type medleys in spatial transcriptomics.	Erdogan NS et al.	—	2025	→
Spatial joint profiling of DNA methylome and transcriptome in tissues.	Lee CN et al.	—	2025	→
Spatially Aware Domain Adaptation Enables Cell Type Deconvolution from Multi-Modal Spatially Resolved Transcriptomics.	Wang L et al.	—	2025	→
Spatial pattern enhanced cellular and tissue recognition for spatial transcriptomics.	Wang Y et al.	—	2025	→
Spatial profiling of chromatin accessibility in formalin-fixed paraffin-embedded tissues.	Guo P et al.	—	2025	→
Spatiotemporal profiling reveals the impact of caloric restriction in the aging mammalian brain.	Zhang Z et al.	—	2025	→
Specification of claustro-amygdalar and palaeocortical neurons and circuits.	Kaur N et al.	—	2025	→
Specific overexpression of contactin-associated protein-like 2 and its effects on pain-related behaviour in mice.	Tseng M et al.	—	2025	→
Spinal lumbar Urocortin 3-expressing neurons are associated with both scratching and Compound 48/80-induced sensations.	Franck MCM et al.	—	2025	→
Spinal sensory innervation of the intestine.	Wolfson RL	—	2025	→
Stimulus-Dependent Expression of <i>Bdnf</i> Is Mediated by ATF2, MYT1L, and EGR1 Transcription Factors.	Esvald EE et al.	—	2025	→
Striatal cell-type-specific molecular signatures reveal potential therapeutic targets in a model of dystonia.	Roman KM et al.	—	2025	→
Structure-function relationships across scales: implications for atlases.	Constable RT	—	2025	→
STsisal: a reference-free deconvolution pipeline for spatial transcriptomics data.	Fu Y et al.	—	2025	→
stTransfer enables transfer of single-cell annotations to spatial transcriptomics with single-cell resolution.	Zhou T et al.	—	2025	→
Suppressing DBNDD2 promotes neuron growth and axon regeneration in adult mammals.	Zhang L et al.	—	2025	→
Targeting Cdc42 improves motor phenotype in Parkinson's disease mice and reveals age-dependent susceptibility to α-synuclein.	Bopp V et al.	—	2025	→
Targeting necrotic lipid release in tumors enhances immunosurveillance and cancer immunotherapy of glioblastoma.	Ji Y et al.	—	2025	→
Targeting sex-specific DRG inflammation and neurofibrosis to prevent Bortezomib-induced neuropathy.	Thomsen MB et al.	—	2025	→
Targeting spinal mechanistic target of rapamycin complex 2 alleviates inflammatory and neuropathic pain.	Wong C et al.	—	2025	→
Targeting TREM2 signaling shows limited impact on cerebrovascular calcification.	Sridhar S et al.	—	2025	→
T cells regulate intestinal motility and shape enteric neuronal responses to intestinal microbiota.	Marques de Souza PR et al.	—	2025	→
Temporal refinement of Dach1 expression contributes to the development of somatosensory neurons.	Szemes T et al.	—	2025	→
The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia.	Toikumo S et al.	—	2025	→
The murine ATP-binding cassette transporter C5 (Abcc5/MRP5/cMOAT) plays a role in memory consolidation, circadian rhythm regulation and glutamatergic signalling.	Banks G et al.	—	2025	→
The neurobiology of parenting and infant-evoked aggression.	Kaplan HS et al.	—	2025	→
The Parkinson's disease DJ-1/PARK7 gene controls peripheral neuronal excitability and painful neuropathy.	Lee SH et al.	—	2025	→
The Physiology of Enteric Glia.	Gonzales J et al.	—	2025	→
The Reversible Neurotoxic Effects of Methylmercury on the Dorsal Root Ganglion: Temporal Dynamics in Rats.	Shinoda Y et al.	—	2025	→
The Role of Metabolites in Cell-Cell Communication: A Review of Databases and Computational Tools.	Song Q et al.	—	2025	→
The role of reactive enteric glia-macrophage interactions in acute and chronic inflammation.	Reiner S et al.	—	2025	→
The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine.	Li W et al.	—	2025	→
The X-Linked Intellectual Disability Gene, ZDHHC9 , Is Important for Oligodendrocyte Subtype Determination and Myelination.	White RB et al.	—	2025	→
TIVelo: RNA velocity estimation leveraging cluster-level trajectory inference.	Ge M et al.	—	2025	→
Tmem45b modulates itch via endoplasmic reticulum calcium regulation.	Wang SS et al.	—	2025	→
Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies.	Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Electronic address: andrew.mcintosh@ed.ac.uk et al.	—	2025	→
Transcriptional Profiling Defines Unique Subtypes of Transit Amplifying Neural Progenitors Within the Neonatal Mouse Subventricular Zone.	Zaritsky R et al.	—	2025	→
Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors.	Zhu M et al.	—	2025	→
Transduction Mechanisms for Cold Temperature in Mouse Trigeminal and Vagal Ganglion Neurons Innervating Different Peripheral Organs.	Gers-Barlag K et al.	—	2025	→
Translatome analysis reveals cellular network in DLK-dependent hippocampal glutamatergic neuron degeneration.	Ritchie EM et al.	—	2025	→
TRESK background potassium channel regulates MrgprA3 + pruriceptor excitability, acute and chronic itch.	Llimós-Aubach J et al.	—	2025	→
Tri-omic single-cell mapping of the 3D epigenome and transcriptome in whole mouse brains throughout the lifespan.	Chai H et al.	—	2025	→
Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense.	Barilla RM et al.	—	2025	→
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus.	O'Keeffe M et al.	—	2025	→
Understanding sensory abnormalities in fibromyalgia through autoantibodies.	Themistocleous AC et al.	—	2025	→
Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis.	Senf K et al.	—	2025	→
Upregulation of delta opioid receptor by meningeal interleukin-10 prevents relapsing pain.	Inyang KE et al.	—	2025	→
Use of Human In Vitro Gut Specimens for Translational Neurogastroenterology and Motility in the 21st Century.	Pavlov D et al.	—	2025	→
Voltage-gated ion channel diversity underlies neuronal excitability and nervous system evolution.	Davila-Velderrain J et al.	—	2025	→
Whole-cortex in situ sequencing reveals input-dependent area identity.	Chen X et al.	—	2025	→
40 years of homeodomain transcription factors in the Drosophila nervous system.	Doe CQ et al.	—	2024	→
Accurate Identification of Spatial Domain by Incorporating Global Spatial Proximity and Local Expression Proximity.	Yu Y et al.	—	2024	→
A chemogenetic screen reveals that Trpv1-expressing neurons control regulatory T cells in the gut.	Zhu Y et al.	—	2024	→
Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain.	Pattison LA et al.	—	2024	→
Adenosine signalling to astrocytes coordinates brain metabolism and function.	Theparambil SM et al.	—	2024	→
Adjustment of scRNA-seq data to improve cell-type decomposition of spatial transcriptomics.	Wang L et al.	—	2024	→
Advancements in Single-Cell RNA Sequencing and Spatial Transcriptomics for Central Nervous System Disease.	Zhang Y et al.	—	2024	→
Aging atlas reveals cell-type-specific effects of pro-longevity strategies.	Gao SM et al.	—	2024	→
aKNNO: single-cell and spatial transcriptomics clustering with an optimized adaptive k-nearest neighbor graph.	Li J et al.	—	2024	→
All-optical reporting of inhibitory receptor driving force in the nervous system.	Selfe JS et al.	—	2024	→
Almost 40 years of studying homeobox genes in C. elegans.	Kratsios P et al.	—	2024	→
Alzheimer's Disease: An Attempt of Total Recall.	Bolshakov AP et al.	—	2024	→
A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes.	Qi L et al.	—	2024	→
Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry.	Benjamin KJM et al.	—	2024	→
Analysis of the neuromuscular deficits caused by STAM1 deficiency.	McLean JW et al.	—	2024	→
An atlas of cells in the human tonsil.	Massoni-Badosa R et al.	—	2024	→
A novel Na<sub>v</sub>1.8-FLPo driver mouse for intersectional genetics to uncover the functional significance of primary sensory neuron diversity.	Malapert P et al.	—	2024	→
APOE from astrocytes restores Alzheimer's Aβ-pathology and DAM-like responses in APOE deficient microglia.	Preman P et al.	—	2024	→
A Review of the Application of Spatial Transcriptomics in Neuroscience.	Zhang L et al.	—	2024	→
A Self-Oscillated Organic Synapse for In-Memory Two-Factor Authentication.	Liu S et al.	—	2024	→
A single-cell atlas of chromatin accessibility in mouse organogenesis.	Sun K et al.	—	2024	→
A single-cell transcriptomic landscape of cadmium-hindered brain development in mice.	Ma Q et al.	—	2024	→
A specific olfactory bulb interneuron subtype Tpbg/5T4 generated at embryonic and neonatal stages.	Tsuboi A	—	2024	→
Astrocyte-derived apolipoprotein D is required for neuronal survival in Parkinson's disease.	Dai Y et al.	—	2024	→
Astrocytes phenomics as new druggable targets in healthy aging and Alzheimer's disease progression.	Lana D et al.	—	2024	→
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease.	Serrano-Pozo A et al.	—	2024	→
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.	Megagiannis P et al.	—	2024	→
A vagal-brainstem interoceptive circuit for cough-like defensive behaviors in mice.	Gannot N et al.	—	2024	→
A γδ T cell-IL-3 axis controls allergic responses through sensory neurons.	Flayer CH et al.	—	2024	→
Bayesian Rare Variant Analysis Identifies Novel Schizophrenia Putative Risk Genes.	Han S	—	2024	→
Beyond classical immunity: Mast cells as signal converters between tissues and neurons.	Plum T et al.	—	2024	→
Beyond Quiescent and Active: Intermediate Microglial Transcriptomic States in a Mouse Model of Down Syndrome.	Fernández-Blanco Á et al.	—	2024	→
Botulinum toxin type A-targeted SPP1 contributes to neuropathic pain by the activation of microglia pyroptosis.	Chen LP et al.	—	2024	→
BrainCellR: A precise cell type nomenclature pipeline for comparative analysis across brain single-cell datasets.	Chi Y et al.	—	2024	→
Brain endothelial GSDMD activation mediates inflammatory BBB breakdown.	Wei C et al.	—	2024	→
BrainTACO: an explorable multi-scale multi-modal brain transcriptomic and connectivity data resource.	Ganglberger F et al.	—	2024	→
Catalytic isoforms of AMP-activated protein kinase differentially regulate IMPDH activity and photoreceptor neuron function.	Lee TJ et al.	—	2024	→
Cell Heterogeneity and Variability in Peripheral Nerve after Injury.	Ren Z et al.	—	2024	→
Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology.	Kukanja P et al.	—	2024	→
CHAI: consensus clustering through similarity matrix integration for cell-type identification.	Lodi MK et al.	—	2024	→
Characteristics of blood-brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells.	Pfau SJ et al.	—	2024	→
Chemogenetic activation of astrocytes modulates sleep-wakefulness states in a brain region-dependent manner.	Kurogi Y et al.	—	2024	→
ciRS-7 and miR-7 regulate ischemia-induced neuronal death via glutamatergic signaling.	Scoyni F et al.	—	2024	→
Claustrum and dorsal endopiriform cortex complex cell-identity is determined by Nurr1 and regulates hallucinogenic-like states in mice.	Mantas I et al.	—	2024	→
Clonally heritable gene expression imparts a layer of diversity within cell types.	Mold JE et al.	—	2024	→
Comparative Physiology and Morphology of BLA-Projecting NBM/SI Cholinergic Neurons in Mouse and Macaque.	Luo F et al.	—	2024	→
Comparison of wholemount dissection methods for neuronal subtype marker expression in the mouse myenteric plexus.	Gomez-Frittelli J et al.	—	2024	→
Crosstalk between peripheral inflammation and brain: Focus on the responses of microglia and astrocytes to peripheral challenge.	Geloso MC et al.	—	2024	→
Decoding the spatiotemporal regulation of transcription factors during human spinal cord development.	Shi Y et al.	—	2024	→
Dihydroartemisinin Modulates Enteric Glial Cell Heterogeneity to Alleviate Colitis.	Qiu P et al.	—	2024	→
Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch.	Balzulat A et al.	—	2024	→
Dissecting the spatiotemporal diversity of adult neural stem cells.	Mitic N et al.	—	2024	→
Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain.	Gan S et al.	—	2024	→
Drug targeting in psychiatric disorders - how to overcome the loss in translation?	Khodosevich K et al.	—	2024	→
EAGS: efficient and adaptive Gaussian smoothing applied to high-resolved spatial transcriptomics.	Lv T et al.	—	2024	→
Effects of nitrous oxide and ketamine on electrophysiological and molecular responses in the prefrontal cortex of mice: A comparative study.	Rozov S et al.	—	2024	→
Enteric glia as friends and foes of the intestinal epithelial barrier function.	Bali V et al.	—	2024	→
Enteric Nervous System Striped Patterning and Disease: Unexplored Pathophysiology.	Dershowitz LB et al.	—	2024	→
ephrin-B2 promotes nociceptive plasticity and hyperalgesic priming through EphB2-MNK-eIF4E signaling in both mice and humans.	David ET et al.	—	2024	→
Exome sequencing identifies genes associated with sleep-related traits.	Fei CJ et al.	—	2024	→
Explainable deep neural networks for predicting sample phenotypes from single-cell transcriptomics.	Martorell-Marugán J et al.	—	2024	→
Ezrin, a novel marker of ependymal cells, can be used to demonstrate their proliferation regulation after spinal cord injury in mice.	Zhang L et al.	—	2024	→
Fetal origins of obesity: a novel pathway of regulating appetite neurons in the hypothalamus of growth-restricted rat offspring.	Han W et al.	—	2024	→
Fiber photometry-based investigation of brain function and dysfunction.	Byron N et al.	—	2024	→
FOXP1 regulates the development of excitatory synaptic inputs onto striatal neurons and induces phenotypic reversal with reinstatement.	Khandelwal N et al.	—	2024	→
From diversity to disease: unravelling the role of enteric glial cells.	Santhosh S et al.	—	2024	→
Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer's and related dementias.	Yin T et al.	—	2024	→
Functional Optimization in Distinct Tissues and Conditions Constrains the Rate of Protein Evolution.	Usmanova DR et al.	—	2024	→
Functional profiling of murine glioma models highlights targetable immune evasion phenotypes.	Mikolajewicz N et al.	—	2024	→
Functional remodeling of presynaptic voltage-gated calcium channels in superficial layers of the dorsal horn during neuropathic pain.	Ferron L et al.	—	2024	→
Generation of Mammalian Astrocyte Functional Heterogeneity.	Bartels T et al.	—	2024	→
Generation of rat forebrain tissues in mice.	Huang J et al.	—	2024	→
Glial modulation of synapse development and plasticity: oligodendrocyte precursor cells as a new player in the synaptic quintet.	Akinlaja YO et al.	—	2024	→
Graph domain adaptation-based framework for gene expression enhancement and cell type identification in large-scale spatially resolved transcriptomics.	Shen R et al.	—	2024	→
Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia.	Bhuiyan SA et al.	—	2024	→
HC-HA/PTX3 from Human Amniotic Membrane Induced Differential Gene Expressions in DRG Neurons: Insights into the Modulation of Pain.	He SQ et al.	—	2024	→
Heterogeneous brain distribution of bumetanide following systemic administration in rats.	Löscher W et al.	—	2024	→
High-resolution omics of vascular ageing and inflammatory pathways in neurodegeneration.	Kwok AJ et al.	—	2024	→
Identification of a postnatal period of interdependent neurogenesis and apoptosis in peripheral neurons.	Kaminski CL et al.	—	2024	→
Identifying cell states in single-cell RNA-seq data at statistically maximal resolution.	Grobecker P et al.	—	2024	→
Immunohistochemical phenotype of sensory neurons associated with sympathetic plexuses in the trigeminal ganglia of adult nerve growth factor transgenic mice.	Alsaadi H et al.	—	2024	→
Impact of Enteric Nervous Cells on Irritable Bowel Syndrome: Potential Treatment Options.	Pastras P et al.	—	2024	→
Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice.	Defaye M et al.	—	2024	→
In situ Patch-seq analysis of microglia reveals a lack of stress genes as found in FACS-isolated microglia.	Bakina O et al.	—	2024	→
Interindividual Variation in Gut Nitrergic Neuron Density Is Regulated By GDNF Levels and ETV1.	Virtanen HT et al.	—	2024	→
Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response.	de Souza S et al.	—	2024	→
Interneuron diversity in the human dorsal striatum.	Garma LD et al.	—	2024	→
Is FAM19A5 an adipokine? Peripheral FAM19A5 in wild-type, FAM19A5 knockout, and LacZ knockin mice.	Kwak H et al.	—	2024	→
Kappa opioids inhibit spinal output neurons to suppress itch.	Sheahan TD et al.	—	2024	→
Knockout of the longevity gene Klotho perturbs aging and Alzheimer's disease-linked brain microRNAs and tRNA fragments.	Dubnov S et al.	—	2024	→
Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation.	Yu H et al.	—	2024	→
LIANA+ provides an all-in-one framework for cell-cell communication inference.	Dimitrov D et al.	—	2024	→
Light affects the prefrontal cortex via intrinsically photosensitive retinal ganglion cells.	Lazzerini Ospri L et al.	—	2024	→
Loss of Function in the Neurodevelopmental Disease and Schizophrenia-Associated Gene CYFIP1 in Human Microglia-like Cells Supports a Functional Role in Synaptic Engulfment.	Sheridan SD et al.	—	2024	→
Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease.	Khan SS et al.	—	2024	→
Loss of TREM2 diminishes CAA despite an overall increase of amyloid load in Tg-SwDI mice.	Zhong R et al.	—	2024	→
<i>ELP1</i>, the Gene Mutated in Familial Dysautonomia, Is Required for Normal Enteric Nervous System Development and Maintenance and for Gut Epithelium Homeostasis.	Chaverra M et al.	—	2024	→
Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex.	Di Bella DJ et al.	—	2024	→
Mapping Cell Atlases at the Single-Cell Level.	Ye F et al.	—	2024	→
Melatonin is a potential novel analgesic agent for osteoarthritis: Evidence from cohort studies in humans and preclinical research in rats.	Li H et al.	—	2024	→
Metabolic Control of Microglia.	Garcia-Segura ME et al.	—	2024	→
Metabolic dynamics in astrocytes and microglia during post-natal development and their implications for autism spectrum disorders.	Cantando I et al.	—	2024	→
Microglial Modulation of Synaptic Maturation, Activity, and Plasticity.	Pinto MJ et al.	—	2024	→
Microglial TNFα controls daily changes in synaptic GABAARs and sleep slow waves.	Pinto MJ et al.	—	2024	→
Molecular diversity and migration of GABAergic neurons in the developing ventral midbrain.	Düdükcü Ö et al.	—	2024	→
Molecular Ontology of the Nucleus of Solitary Tract.	Gasparini S et al.	—	2024	→
Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage.	Vázquez-Liébanas E et al.	—	2024	→
MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model.	Chien DC et al.	—	2024	→
Multimodal Nature of the Single-cell Primate Brain Atlas: Morphology, Transcriptome, Electrophysiology, and Connectivity.	Shen Y et al.	—	2024	→
Multipotent progenitors instruct ontogeny of the superior colliculus.	Cheung G et al.	—	2024	→
Multiscale topology classifies cells in subcellular spatial transcriptomics.	Benjamin K et al.	—	2024	→
Muscularis macrophages controlled by NLRP3 maintain the homeostasis of excitatory neurons.	Gao Y et al.	—	2024	→
Myeloid cell replacement is neuroprotective in chronic experimental autoimmune encephalomyelitis.	Mader MM et al.	—	2024	→
Navigating the blurred path of mixed neuroimmune signaling.	Gupta S et al.	—	2024	→
Neurogenesis in Caenorhabditis elegans.	Poole RJ et al.	—	2024	→
Neuroimmune Interactions in the Intestine.	Wallrapp A et al.	—	2024	→
Neuroimmunophysiology of the gastrointestinal tract.	McKay DM et al.	—	2024	→
Neuronal cell populations in circumoral nerve ring of sea cucumber Apostichopus japonicus: Ultrastructure and transcriptional profile.	Zheng Y et al.	—	2024	→
Neuron-glia crosstalk and inflammatory mediators in migraine pathophysiology.	Song Y et al.	—	2024	→
Neuron-specific chromatin disruption at CpG islands and aging-related regions in Kabuki syndrome mice.	Boukas L et al.	—	2024	→
New evidence of vascular defects in neurodegenerative diseases revealed by single cell RNA sequencing.	Qiu J et al.	—	2024	→
New insights into the physiology and pathophysiology of the atypical sodium leak channel NALCN.	Monteil A et al.	—	2024	→
Ngfr<sup>+</sup> cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory.	Mei F et al.	—	2024	→
NMDA Receptors in Neurodevelopmental Disorders: Pathophysiology and Disease Models.	Tumdam R et al.	—	2024	→
Nonsynonymous Mutations in Intellectual Disability and Autism Spectrum Disorder Gene PTCHD1 Disrupt <i>N</i>-Glycosylation and Reduce Protein Stability.	Xie CTY et al.	—	2024	→
Obesity and the cerebral cortex: Underlying neurobiology in mice and humans.	Patel Y et al.	—	2024	→
Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity.	Miyazaki Y et al.	—	2024	→
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.	Sasmita AO et al.	—	2024	→
Out of the dark: the emerging roles of lncRNAs in pain.	Habib AM et al.	—	2024	→
Pericytes: jack-of-all-trades in cancer-related inflammation.	Moro M et al.	—	2024	→
Peripheral gating of mechanosensation by glial diazepam binding inhibitor.	Li X et al.	—	2024	→
Prediction of cell-cell communication patterns of dorsal root ganglion cells: single-cell RNA sequencing data analysis.	Lian Y et al.	—	2024	→
Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure.	Ganji-Arjenaki M et al.	—	2024	→
Protocol for mapping cell lineage and cell-type identity of clonally-related cells in situ using MADM-CloneSeq.	Cheung G et al.	—	2024	→
Reactive astrocytes in prion diseases: Friend or foe?	Makarava N et al.	—	2024	→
Reconstruction of macroglia and adult neurogenesis evolution through cross-species single-cell transcriptomic analyses.	Morizet D et al.	—	2024	→
Recovering single-cell expression profiles from spatial transcriptomics with scResolve.	Chen H et al.	—	2024	→
Relationship between sex biases in gene expression and sex biases in autism and Alzheimer's disease.	Fass SB et al.	—	2024	→
Repeated LPS induces training and tolerance of microglial responses across brain regions.	Kim J et al.	—	2024	→
Role of pattern recognition receptors in chemotherapy-induced neuropathic pain.	Araldi D et al.	—	2024	→
SATB2 organizes the 3D genome architecture of cognition in cortical neurons.	Wahl N et al.	—	2024	→
scEVOLVE: cell-type incremental annotation without forgetting for single-cell RNA-seq data.	Zhai Y et al.	—	2024	→
scGIST: gene panel design for spatial transcriptomics with prioritized gene sets.	Yafi MA et al.	—	2024	→
scGraphformer: unveiling cellular heterogeneity and interactions in scRNA-seq data using a scalable graph transformer network.	Fan X et al.	—	2024	→
Shaping the olfactory map: cell type-specific activity patterns guide circuit formation.	Nakashima A et al.	—	2024	→
Shared inflammatory glial cell signature after stab wound injury, revealed by spatial, temporal, and cell-type-specific profiling of the murine cerebral cortex.	Koupourtidou C et al.	—	2024	→
Shrinkage estimation of gene interaction networks in single-cell RNA sequencing data.	Vo DHT et al.	—	2024	→
Single-cell analysis of innate spinal cord regeneration identifies intersecting modes of neuronal repair.	Saraswathy VM et al.	—	2024	→
Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica.	Skinnider MA et al.	—	2024	→
Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems.	Zenk F et al.	—	2024	→
Single-cell investigation of lead toxicity from neurodevelopment to neurodegeneration: Current review and future opportunities.	Sampson MM et al.	—	2024	→
Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain.	Joglekar A et al.	—	2024	→
Single-cell multiregion dissection of Alzheimer's disease.	Mathys H et al.	—	2024	→
Single-Cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations.	Sagi D et al.	—	2024	→
Single-cell sequencing analysis within biologically relevant dimensions.	Kousnetsov R et al.	—	2024	→
Single-cell sequencing reveals glial cell involvement in development of neuropathic pain via myelin sheath lesion formation in the spinal cord.	Li D et al.	—	2024	→
Single-cell sequencing technology in skin wound healing.	Cheng XC et al.	—	2024	→
Single cell spatial biology over developmental time can decipher pediatric brain pathologies.	Nussinov R et al.	—	2024	→
Single-Cell Transcriptome Landscape and Cell Fate Decoding in Human Brain Organoids after Transplantation.	Xu SB et al.	—	2024	→
Single-nucleus RNA-seq identifies one galanin neuronal subtype in mouse preoptic hypothalamus activated during recovery from sleep deprivation.	Guo X et al.	—	2024	→
Single-nucleus RNA sequencing reveals glial cell type-specific responses to ischemic stroke in male rodents.	Bormann D et al.	—	2024	→
Slitrk4 is required for the development of inhibitory neurons in the fear memory circuit of the lateral amygdala.	Matsumoto Y et al.	—	2024	→
Small Molecule Hydrogels Loading Small Molecule Drugs from Chinese Medicine for the Enhanced Treatment of Traumatic Brain Injury.	Luo W et al.	—	2024	→
SMART: spatial transcriptomics deconvolution using marker-gene-assisted topic model.	Yang CX et al.	—	2024	→
Spatial analysis toolkits for RNA in situ sequencing.	Chen J et al.	—	2024	→
SpatialcoGCN: deconvolution and spatial information-aware simulation of spatial transcriptomics data via deep graph co-embedding.	Yin W et al.	—	2024	→
Spatial gene expression profile of Wnt-signaling components in the murine enteric nervous system.	Scharr M et al.	—	2024	→
spatiAlign: an unsupervised contrastive learning model for data integration of spatially resolved transcriptomics.	Zhang C et al.	—	2024	→
Spatially resolved cell atlas of the teleost telencephalon and deep homology of the vertebrate forebrain.	Hegarty BE et al.	—	2024	→
Spatial multimodal analysis of transcriptomes and metabolomes in tissues.	Vicari M et al.	—	2024	→
Spatial, transcriptomic, and epigenomic analyses link dorsal horn neurons to chronic pain genetic predisposition.	Arokiaraj CM et al.	—	2024	→
Spatiotemporal transcriptomic map of glial cell response in a mouse model of acute brain ischemia.	Zucha D et al.	—	2024	→
Spinal Glycine Receptor Alpha 3 Cells Communicate Sensations of Chemical Itch in Hairy Skin.	Weman HM et al.	—	2024	→
Strategies for dissecting the complexity of neurodevelopmental disorders.	Sun J et al.	—	2024	→
Striatal projection neurons coexpressing dopamine D1 and D2 receptors modulate the motor function of D1- and D2-SPNs.	Bonnavion P et al.	—	2024	→
Supermultipotency and unpredictability in the developing superior colliculus.	Rudenko A et al.	—	2024	→
Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis.	Bai Z et al.	—	2024	→
Systematic comparison of sequencing-based spatial transcriptomic methods.	You Y et al.	—	2024	→
Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response.	Germeys C et al.	—	2024	→
Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier.	Barker SJ et al.	—	2024	→
The Afferent Function of Adipose Innervation.	Wang Y et al.	—	2024	→
The brain atlas of a subsocial bee reflects that of eusocial Hymenoptera.	Pyenson BC et al.	—	2024	→
The cell-type-specific spatial organization of the anterior thalamic nuclei of the mouse brain.	Kapustina M et al.	—	2024	→
The 'dispanins' and related proteins in physiology and neurological disease.	Deuis JR et al.	—	2024	→
The genetic architecture of youth anxiety: a study protocol.	McAusland L et al.	—	2024	→
The Mas-related G protein-coupled receptor d (Mrgprd) mediates pain hypersensitivity in painful diabetic neuropathy.	George DS et al.	—	2024	→
The mRNA expression profile of glycine receptor subunits alpha 1, alpha 2, alpha 4 and beta in female and male mice.	Ceder MM et al.	—	2024	→
The nociceptive activity of peripheral sensory neurons is modulated by the neuronal membrane proteasome.	Villalón Landeros E et al.	—	2024	→
The Role of Glial Cells in Neurobiology and Prion Neuropathology.	Hay A et al.	—	2024	→
Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update.	Vargas Y et al.	—	2024	→
Tissue module discovery in single-cell-resolution spatial transcriptomics data via cell-cell interaction-aware cell embedding.	Li Y et al.	—	2024	→
Topographical and cell type-specific connectivity of rostral and caudal forelimb corticospinal neuron populations.	Carmona LM et al.	—	2024	→
Topographic Organization of Glutamatergic and GABAergic Parvalbumin-Positive Neurons in the Lateral Habenula.	Nguyen TVT et al.	—	2024	→
Tri-omic mapping revealed concerted dynamics of 3D epigenome and transcriptome in brain cells	Chai H et al.	—	2024	—
Uncovering functional lncRNAs by scRNA-seq with ELATUS.	Goñi E et al.	—	2024	→
West Nile virus triggers intestinal dysmotility via T cell-mediated enteric nervous system injury.	Janova H et al.	—	2024	→
Where Top-Down Meets Bottom-Up: Cell-Type Specific Connectivity Map of the Whisker System.	Rault N et al.	—	2024	→
Whole-brain spatial transcriptional analysis at cellular resolution.	Kanatani S et al.	—	2024	→
Widespread co-release of glutamate and GABA throughout the mouse brain.	Ceballos CC et al.	—	2024	→
ZEBRA: a hierarchically integrated gene expression atlas of the murine and human brain at single-cell resolution.	Flotho M et al.	—	2024	→
150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility.	Wu Y et al.	—	2023	→
A Carboxy-terminal Smarcb1 Point Mutation Induces Hydrocephalus Formation and Affects AP-1 and Neuronal Signalling Pathways in Mice.	Brugmans AK et al.	—	2023	→
Accurate classification of major brain cell types using in vivo imaging and neural network processing.	Das Gupta A et al.	—	2023	→
A cell marker-based clustering strategy (cmCluster) for precise cell type identification of scRNA-seq data.	Huang Y et al.	—	2023	→
A cellular taxonomy of the adult human spinal cord.	Yadav A et al.	—	2023	→
Acid-sensing ion channel 3 is required for agmatine-induced histamine-independent itch in mice.	Zhou GK et al.	—	2023	→
A combinatorial panel for flow cytometry-based isolation of enteric nervous system cells from human intestine.	Windster JD et al.	—	2023	→
A comparative atlas of single-cell chromatin accessibility in the human brain.	Li YE et al.	—	2023	→
A comparison of the impact on neuronal transcriptome and cognition of rAAV5 transduction with three different doses in the mouse hippocampus.	Liu YS et al.	—	2023	→
Adult neurogenesis in the primate hippocampus.	Li Y et al.	—	2023	→
Advantages of omics approaches for elucidating metabolic changes in diabetic peripheral neuropathy.	Yako H et al.	—	2023	→
Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease.	Kulkarni S et al.	—	2023	→
A global view of aging and Alzheimer's pathogenesis-associated cell population dynamics and molecular signatures in human and mouse brains.	Sziraki A et al.	—	2023	→
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain.	Yao Z et al.	—	2023	→
A lamprey neural cell type atlas illuminates the origins of the vertebrate brain.	Lamanna F et al.	—	2023	→
AllenDigger, a Tool for Spatial Expression Data Visualization, Spatial Heterogeneity Delineation, and Single-Cell Registration Based on the Allen Brain Atlas.	Wang M et al.	—	2023	→
A machine learning based approach for quantitative evaluation of cell migration in Transwell assays based on deformation characteristics.	Zhang F et al.	—	2023	→
A marmoset brain cell census reveals regional specialization of cellular identities.	Krienen FM et al.	—	2023	→
A mast cell-thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis.	Bao C et al.	—	2023	→
Analysis of matrisome expression patterns in murine and human dorsal root ganglia.	Vroman R et al.	—	2023	→
Anatomical contacts between sensory neurons and epidermal cells: an unrecognized anatomical network for neuro-immuno-cutaneous crosstalk.	Talagas M	—	2023	→
An ependymal cell census identifies heterogeneous and ongoing cell maturation in the adult mouse spinal cord that changes dynamically on injury.	Rodrigo Albors A et al.	—	2023	→
An Overview of the Mechanisms Involved in Neuralgia.	Zhang BW et al.	—	2023	→
APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge.	Lee S et al.	—	2023	→
A RhoA-mediated biomechanical response in Schwann cells modulates peripheral nerve myelination.	Seixas AI et al.	—	2023	→
A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature.	Bjørnholm KD et al.	—	2023	→
A single-cell level comparison of human inner ear organoids with the human cochlea and vestibular organs.	van der Valk WH et al.	—	2023	→
A single-cell RNA labeling strategy for measuring stress response upon tissue dissociation.	Neuschulz A et al.	—	2023	→
A single-cell trajectory atlas of striatal development.	Anderson AG et al.	—	2023	→
A single-cell transcriptome atlas of the maturing zebrafish telencephalon.	Pandey S et al.	—	2023	→
A single-cell transcriptome atlas profiles early organogenesis in human embryos.	Xu Y et al.	—	2023	→
Astrocyte heterogeneity and interactions with local neural circuits.	Holt MG	—	2023	→
A telencephalon cell type atlas for goldfish reveals diversity in the evolution of spatial structure and cell types.	Tibi M et al.	—	2023	→
Atlas-scale single-cell chromatin accessibility using nanowell-based combinatorial indexing.	O'Connell BL et al.	—	2023	→
Biology of vascular mural cells.	Siekmann AF	—	2023	→
Bone-derived PDGF-BB drives brain vascular calcification in male mice.	Wang J et al.	—	2023	→
Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function.	Seeker LA et al.	—	2023	→
Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice.	Farsi Z et al.	—	2023	→
Bulk and mosaic deletions of <i>Egfr</i> reveal regionally defined gliogenesis in the developing mouse forebrain.	Zhang X et al.	—	2023	→
Calretinin-expressing islet cells are a source of pre- and post-synaptic inhibition of non-peptidergic nociceptor input to the mouse spinal cord.	Davis OC et al.	—	2023	→
Cell and circuit complexity of the external globus pallidus.	Courtney CD et al.	—	2023	→
Celloscope: a probabilistic model for marker-gene-driven cell type deconvolution in spatial transcriptomics data.	Geras A et al.	—	2023	→
Cell-Specific Gene Expression in the Prenatal Brain and Schizophrenia Risk.	Morris DW	—	2023	→
CellTICS: an explainable neural network for cell-type identification and interpretation based on single-cell RNA-seq data.	Yin Q et al.	—	2023	→
Cell-type-specific densities in mouse somatosensory cortex derived from scRNA-seq and <i>in situ</i> RNA hybridization.	Keller D et al.	—	2023	→
Cell-type specific molecular architecture for mu opioid receptor function in pain and addiction circuits.	Ochandarena NE et al.	—	2023	→
Cellular complexity of the peripheral nervous system: Insights from single-cell resolution.	Zhao L et al.	—	2023	→
Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice.	Dorfman MD et al.	—	2023	→
Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression.	Holloway KN et al.	—	2023	→
Characterisation of NPFF-expressing neurons in the superficial dorsal horn of the mouse spinal cord.	Quillet R et al.	—	2023	→
Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis.	Tsitsou-Kampeli A et al.	—	2023	→
Chronic Morphine Modulates PDGFR-β and PDGF-B Expression and Distribution in Dorsal Root Ganglia and Spinal Cord in Male Rats.	Puig S et al.	—	2023	→
Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation.	Samuels JD et al.	—	2023	→
CIForm as a Transformer-based model for cell-type annotation of large-scale single-cell RNA-seq data.	Xu J et al.	—	2023	→
Conserved multi-tissue transcriptomic adaptations to exercise training in humans and mice.	Moore TM et al.	—	2023	→
Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function.	Jung M et al.	—	2023	→
CTRP13 ablation improves systemic glucose and lipid metabolism.	Chen F et al.	—	2023	→
Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology.	Gaunt JR et al.	—	2023	→
D1- and D2-type dopamine receptors are immunolocalized in pial and layer I astrocytes in the rat cerebral cortex.	Oda S et al.	—	2023	→
Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants <i>in vivo</i>.	Rájová J et al.	—	2023	→
Deep RNA-seq of male and female murine sensory neuron subtypes after nerve injury.	Barry AM et al.	—	2023	→
Deep scRNA sequencing reveals a broadly applicable Regeneration Classifier and implicates antioxidant response in corticospinal axon regeneration.	Kim HJ et al.	—	2023	→
Defining and identifying cell sub-crosstalk pairs for characterizing cell-cell communication patterns.	Zhang C et al.	—	2023	→
Defining Selective Neuronal Resilience and Identifying Targets for Neuroprotection and Axon Regeneration Using Single-Cell RNA Sequencing: Experimental Approaches.	Jacobi A et al.	—	2023	→
Dermal appendage-dependent patterning of zebrafish <i>atoh1a+</i> Merkel cells.	Brown TL et al.	—	2023	→
Direct observation of the evolution of cell-type-specific microRNA expression signatures supports the hematopoietic origin model of endothelial cells.	Jenike AE et al.	—	2023	→
Disruption of the autism gene and chromatin regulator KDM5A alters hippocampal cell identity.	El Hayek L et al.	—	2023	→
Dissecting shared genetic architecture between obesity and multiple sclerosis.	Zeng R et al.	—	2023	→
Distinct Features of Interictal Activity Predict Seizure Localization and Burden in a Mouse Model of Childhood Epilepsy.	Tobin WF et al.	—	2023	→
Distinctiveness and continuity in transcriptome and connectivity in the anterior-posterior axis of the paraventricular nucleus of the thalamus.	Shima Y et al.	—	2023	→
Dopamine inhibits group 2 innate lymphoid cell-driven allergic lung inflammation by dampening mitochondrial activity.	Cao Y et al.	—	2023	→
DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.	Wolfson RL et al.	—	2023	→
Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder.	Park G et al.	—	2023	→
Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease.	Calafate S et al.	—	2023	→
Early growth response 2 in the mPFC regulates mouse social and cooperative behaviors.	Zhang Y et al.	—	2023	→
Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus.	Kos A et al.	—	2023	→
Electrophysiological and morphological features of myenteric neurons of human colon revealed by intracellular recording and dye fills.	Yew WP et al.	—	2023	→
Endogenous neural stem cells characterization using omics approaches: Current knowledge in health and disease.	Murtaj V et al.	—	2023	→
Enteric Neuromics: How High-Throughput "Omics" Deepens Our Understanding of Enteric Nervous System Genetic Architecture.	Dharshika C et al.	—	2023	→
Ethanol-induced cerebellar transcriptomic changes in a postnatal model of fetal alcohol spectrum disorders: Focus on disease onset.	Holloway KN et al.	—	2023	→
Expansion spatial transcriptomics.	Fan Y et al.	—	2023	→
Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development.	Kurki SN et al.	—	2023	→
Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in <i>Caenorhabditis elegans</i>.	Brocal-Ruiz R et al.	—	2023	→
Functional genomics provide key insights to improve the diagnostic yield of hereditary ataxia.	Chen Z et al.	—	2023	→
Gene knockout inference with variational graph autoencoder learning single-cell gene regulatory networks.	Yang Y et al.	—	2023	→
Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration.	Estevez-Fraga C et al.	—	2023	→
Genome-wide association study of hippocampal blood-oxygen-level-dependent-cerebral blood flow correlation in Chinese Han population.	Xue H et al.	—	2023	→
Glial Cell Modulation of Dendritic Spine Structure and Synaptic Function.	Rasia-Filho AA et al.	—	2023	→
Glial Populations in the Human Brain Following Ischemic Injury.	Mihailova V et al.	—	2023	→
GluCl.Cre ON enables selective inhibition of molecularly defined pain circuits.	Middleton SJ et al.	—	2023	→
GPR35 and mediators from platelets and mast cells in neutrophil migration and inflammation.	De Giovanni M et al.	—	2023	→
Gpr83 Tunes Nociceptor Function, Controlling Pain.	Kim Y et al.	—	2023	→
Guardians of the gut: influence of the enteric nervous system on the intestinal epithelial barrier.	Bubeck M et al.	—	2023	→
Gut-oriented disease modifying therapy for Parkinson's disease.	Lin CH et al.	—	2023	→
Harnessing the Power of Enteric Glial Cells' Plasticity and Multipotency for Advancing Regenerative Medicine.	Lefèvre MA et al.	—	2023	→
Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types.	Ximerakis M et al.	—	2023	→
Highly dynamic inflammatory and excitability transcriptional profiles in hippocampal CA1 following status epilepticus.	Galvis-Montes DS et al.	—	2023	→
Highly specific σ<sub>2</sub>R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response.	Yousuf MS et al.	—	2023	→
Human hair follicle-derived mesenchymal stem cells promote tendon repair in a rabbit Achilles tendinopathy model.	Ma Y et al.	—	2023	→
Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding.	Adriaenssens A et al.	—	2023	→
Hypoxic niches attract and sequester tumor-associated macrophages and cytotoxic T cells and reprogram them for immunosuppression.	Sattiraju A et al.	—	2023	→
IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice.	Andreadou M et al.	—	2023	→
IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment.	Zhang J et al.	—	2023	→
IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis.	Fassett MS et al.	—	2023	→
Immune-mediated denervation of the pineal gland underlies sleep disturbance in cardiac disease.	Ziegler KA et al.	—	2023	→
Inducible co-stimulatory molecule (ICOS) alleviates paclitaxel-induced neuropathic pain via an IL-10-mediated mechanism in female mice.	Sankaranarayanan I et al.	—	2023	→
Infernape uncovers cell type-specific and spatially resolved alternative polyadenylation in the brain.	Kang B et al.	—	2023	→
Inferring single-cell transcriptomic dynamics with structured latent gene expression dynamics.	Farrell S et al.	—	2023	→
Ingestion of <i>Lacticaseibacillus rhamnosus</i> Fmb14 prevents depression-like behavior and brain neural activity <i>via</i> the microbiota-gut-brain axis in colitis mice.	Zhao H et al.	—	2023	→
Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold.	Albisetti GW et al.	—	2023	→
Inhibitory neuron map of sevoflurane induced neurotoxicity model in young primates.	Niu Y et al.	—	2023	→
Insights into Alzheimer's disease from single-cell genomic approaches.	Murdock MH et al.	—	2023	→
Integrating multi-modal information to detect spatial domains of spatial transcriptomics by graph attention network.	Huo Y et al.	—	2023	→
Integrating spatial transcriptomics data across different conditions, technologies and developmental stages.	Zhou X et al.	—	2023	→
Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer's disease.	Zeng H et al.	—	2023	→
Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis.	Mosquera JV et al.	—	2023	→
Intestinal distension orchestrates neuronal activity in the enteric nervous system of adult mice.	Cavin JB et al.	—	2023	→
<i>Ret</i> deficiency decreases neural crest progenitor proliferation and restricts fate potential during enteric nervous system development.	Vincent E et al.	—	2023	→
Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis.	Wang S et al.	—	2023	→
Keratinocyte TLR2 and TLR7 contribute to chronic itch through pruritic cytokines and chemokines in mice.	Wang ZH et al.	—	2023	→
Key elements determining the intestinal region-specific environment of enteric neurons in type 1 diabetes.	Bagyánszki M et al.	—	2023	→
K<sub>V</sub>7 but not dual small and intermediate K<sub>Ca</sub> channel openers inhibit the activation of colonic afferents by noxious stimuli.	Bhebhe CN et al.	—	2023	→
Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners.	Xu Y et al.	—	2023	→
Landscape of mast cell populations across organs in mice and humans.	Tauber M et al.	—	2023	→
Large-Area Field Potential Imaging Having Single Neuron Resolution Using 236 880 Electrodes CMOS-MEA Technology.	Suzuki I et al.	—	2023	→
Limited expression of Nrf2 in neurons across the central nervous system.	Levings DC et al.	—	2023	→
Loss of ASD-related molecule Cntnap2 affects colonic motility in mice.	Robinson BG et al.	—	2023	→
Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system-No evidence for the role of neuronal P2X7 receptors in colitis.	Jooss T et al.	—	2023	→
Manifold learning for fMRI time-varying functional connectivity.	Gonzalez-Castillo J et al.	—	2023	→
Mapping of clonal lineages across developmental stages in human neural differentiation.	You Z et al.	—	2023	→
MASI enables fast model-free standardization and integration of single-cell transcriptomics data.	Xu Y et al.	—	2023	→
Mast cells link immune sensing to antigen-avoidance behaviour.	Plum T et al.	—	2023	→
Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation.	Pokrajac NT et al.	—	2023	→
Meta-Analyses of Genome-Wide Association Studies for Postpartum Depression.	Guintivano J et al.	—	2023	→
Meta-topologies define distinct anatomical classes of brain tumours linked to histology and survival.	Kernbach JM et al.	—	2023	→
Meteorin Alleviates Paclitaxel-Induced Peripheral Neuropathic Pain in Mice.	Sankaranarayanan I et al.	—	2023	→
Microglial TNFα orchestrates protein phosphorylation in the cortex during the sleep period and controls homeostatic sleep.	Pinto MJ et al.	—	2023	→
Migraine and major depression: localizing shared genetic susceptibility in different cell types of the nervous systems.	Androulakis XM et al.	—	2023	→
Mini-review: Enteric glial cell heterogeneity: Is it all about the niche?	Sanchini G et al.	—	2023	→
Mini-Review: Enteric glia of the tumor microenvironment: An affair of corruption.	Mariant CL et al.	—	2023	→
Mini-review: Intercellular communication between enteric glia and neurons.	Thomasi B et al.	—	2023	→
MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion.	Shiers S et al.	—	2023	→
Modulating the activity of human nociceptors with a SCN10A promoter-specific viral vector tool.	Mouchbahani-Constance S et al.	—	2023	→
Molecular anatomy of adult mouse leptomeninges.	Pietilä R et al.	—	2023	→
Molecular and cellular evolution of the amygdala across species analyzed by single-nucleus transcriptome profiling.	Yu B et al.	—	2023	→
Molecular and spatial signatures of mouse brain aging at single-cell resolution.	Allen WE et al.	—	2023	→
Molecular consequences of peripheral Influenza A infection on cell populations in the murine hypothalamus.	Lemcke R et al.	—	2023	→
Molecular determinants of TRPM8 function: key clues for a cool modulation.	Pertusa M et al.	—	2023	→
Molecular Diversity of Neuron Types in the Salamander Amygdala and Implications for Amygdalar Evolution.	Deryckere A et al.	—	2023	→
Molecularly defined and spatially resolved cell atlas of the whole mouse brain.	Zhang M et al.	—	2023	→
Molecular taxonomy of nociceptors and pruriceptors.	Kupari J et al.	—	2023	→
Mouse Spinal Cord Vascular Transcriptome Analysis Identifies CD9 and MYLIP as Injury-Induced Players.	Martins I et al.	—	2023	→
mRNA isoform balance in neuronal development and disease.	LaForce GR et al.	—	2023	→
Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag.	Bartosovic M et al.	—	2023	→
Multimodal deep learning approaches for single-cell multi-omics data integration.	Athaya T et al.	—	2023	→
Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer's disease model mice.	Lu Y et al.	—	2023	→
N-acetylneuraminic acid links immune exhaustion and accelerated memory deficit in diet-induced obese Alzheimer's disease mouse model.	Suzzi S et al.	—	2023	→
Neural cell isolation from adult macaques for high-throughput analyses and neurosphere cultures.	Wei JR et al.	—	2023	→
Neurexin-2: An inhibitory neurexin that restricts excitatory synapse formation in the hippocampus.	Lin PY et al.	—	2023	→
Neurodegeneration cell per cell.	Balusu S et al.	—	2023	→
Neurodevelopmental deficits and cell-type-specific transcriptomic perturbations in a mouse model of HNRNPU haploinsufficiency.	Dugger SA et al.	—	2023	→
Neuroimmune interactions in atopic and allergic contact dermatitis.	Liu AW et al.	—	2023	→
Neuroinflammation: An astrocyte perspective.	Lee HG et al.	—	2023	→
Neuronal identity defines α-synuclein and tau toxicity.	Praschberger R et al.	—	2023	→
Neuronal NLRP3 inflammasome mediates spreading depolarization-evoked trigeminovascular activation.	Chen PY et al.	—	2023	→
Neuronal types in the mouse amygdala and their transcriptional response to fear conditioning.	Hochgerner H et al.	—	2023	→
Neuroplasticity and regeneration after spinal cord injury.	Punjani N et al.	—	2023	→
Notch signaling is activated in knee-innervating dorsal root ganglia in experimental models of osteoarthritis joint pain.	Wang L et al.	—	2023	→
On the origin and development of glioblastoma: multifaceted role of perivascular mesenchymal stromal cells.	Ah-Pine F et al.	—	2023	→
Organoid models of breathing disorders reveal patterning defect of hindbrain neurons caused by PHOX2B-PARMs.	Lui KN et al.	—	2023	→
Overnight Corticosterone and Gene Expression in Mouse Hippocampus: Time Course during Resting Period.	Jaszczyk A et al.	—	2023	→
Pain-causing stinging nettle toxins target TMEM233 to modulate Na<sub>V</sub>1.7 function.	Jami S et al.	—	2023	→
Palmitoylation-dependent control of JAK1 kinase signaling governs responses to neuropoietic cytokines and survival in DRG neurons.	Hernandez LM et al.	—	2023	→
Pamoic acid-induced peripheral GPR35 activation improves pruritus and dermatitis.	Kim C et al.	—	2023	→
Patch-seq: Advances and Biological Applications.	Shao M et al.	—	2023	→
Pathogen recognition by sensory neurons: hypotheses on the specificity of sensory neuron signaling.	Millet A et al.	—	2023	→
PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior.	Zhao J et al.	—	2023	→
Pediatric-Onset Epilepsy and Developmental Epileptic Encephalopathies Followed by Early-Onset Parkinsonism.	Spagnoli C et al.	—	2023	→
Peptidergic and functional delineation of the Edinger-Westphal nucleus.	Priest MF et al.	—	2023	→
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease.	De Schepper S et al.	—	2023	→
Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis.	Obeidat AM et al.	—	2023	→
PIEZO2 in somatosensory neurons controls gastrointestinal transit.	Servin-Vences MR et al.	—	2023	→
Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data.	Ma Y et al.	—	2023	→
Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia.	Vermeiren S et al.	—	2023	→
Profiling spatiotemporal gene expression of the developing human spinal cord and implications for ependymoma origin.	Li X et al.	—	2023	→
Psychological stress induces an increase in cholinergic enteric neuromuscular pathways mediated by glucocorticoid receptors.	Blin J et al.	—	2023	→
Quantitative Spatial Analysis of Neuroligin-3 mRNA Expression in the Enteric Nervous System Reveals a Potential Role in Neuronal-Glial Synapses and Reduced Expression in <i>Nlgn3<sup>R451C</sup></i> Mice.	Herath M et al.	—	2023	→
Range of chromatin accessibility configurations are permissive of GABAergic fate acquisition in developing mouse brain.	Kilpinen S et al.	—	2023	→
Rapid and Robust Multi-Phenotypic Assay System for ALS Using Human iPS Cells with Mutations in Causative Genes.	Kondo T et al.	—	2023	→
Reconstructing mutational lineages in breast cancer by multi-patient-targeted single-cell DNA sequencing.	Leighton J et al.	—	2023	→
Recovery of missing single-cell RNA-sequencing data with optimized transcriptomic references.	Pool AH et al.	—	2023	→
Recovery of walking after paralysis by regenerating characterized neurons to their natural target region.	Squair JW et al.	—	2023	→
Redistribution of the astrocyte phenotypes in the medial vestibular nuclei after unilateral labyrinthectomy.	Li J et al.	—	2023	→
RefTM: reference-guided topic modeling of single-cell chromatin accessibility data.	Zhang Z et al.	—	2023	→
Region-Specific Homeostatic Identity of Astrocytes Is Essential for Defining Their Response to Pathological Insults.	Makarava N et al.	—	2023	→
Revisiting the expression of BDNF and its receptors in mammalian development.	Esvald EE et al.	—	2023	→
RNA Sequencing and Spatial Transcriptomics in Traumatic Spinal Cord Injury (Review).	Chelyshev YA et al.	—	2023	→
Role of the Peripheral Nervous System in Skeletal Development and Regeneration: Controversies and Clinical Implications.	Hassan MG et al.	—	2023	→
Role of TMEM100 in mechanically insensitive nociceptor un-silencing.	Nees TA et al.	—	2023	→
Role of Type I Cannabinoid Receptor in Sensory Neurons in Psoriasiform Skin Inflammation and Pruritus.	Liu X et al.	—	2023	→
S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.	Deng L et al.	—	2023	→
Scalable in situ single-cell profiling by electrophoretic capture of mRNA using EEL FISH.	Borm LE et al.	—	2023	→
scEvoNet: a gradient boosting-based method for prediction of cell state evolution.	Kotov A et al.	—	2023	→
scGAD: a new task and end-to-end framework for generalized cell type annotation and discovery.	Zhai Y et al.	—	2023	→
Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch.	Takahashi S et al.	—	2023	→
Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation.	Najjar SA et al.	—	2023	→
Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons.	Shen BQ et al.	—	2023	→
Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus.	Brivio E et al.	—	2023	→
Single-cell analysis of dorsal root ganglia reveals metalloproteinase signaling in satellite glial cells and pain.	Tonello R et al.	—	2023	→
Single-cell analysis of the postnatal dorsal V-SVZ reveals a role for Bmpr1a signaling in silencing pallial germinal activity.	Marcy G et al.	—	2023	→
Single-cell analysis reveals specific neuronal transition during mouse corticogenesis.	Zhou Z et al.	—	2023	→
Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease.	Piwecka M et al.	—	2023	→
Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain.	Liu H et al.	—	2023	→
Single-cell genomics reveals region-specific developmental trajectories underlying neuronal diversity in the human hypothalamus.	Herb BR et al.	—	2023	→
Single-cell multiome sequencing clarifies enteric glial diversity and identifies an intraganglionic population poised for neurogenesis.	Guyer RA et al.	—	2023	→
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice.	Park H et al.	—	2023	→
Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex.	Chen A et al.	—	2023	→
Single-cell transcriptomic analysis reveals diversity within mammalian spinal motor neurons.	Liau ES et al.	—	2023	→
Single-cell transcriptomic landscape of the developing human spinal cord.	Andersen J et al.	—	2023	→
Single-cell transcriptomic profiling of dorsal root ganglion: an overview.	Xie K et al.	—	2023	→
Single-cell transcriptomics identifies perturbed molecular pathways in midbrain organoids using α-synuclein triplication Parkinson's disease patient-derived iPSCs.	Patikas N et al.	—	2023	→
Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition.	Zhou JL et al.	—	2023	→
Sodium appetite and thirst do not require angiotensinogen production in astrocytes or hepatocytes.	Peltekian L et al.	—	2023	→
Somatic CNV Detection by Single-Cell Whole-Genome Sequencing in Postmortem Human Brain.	Perez-Rodriguez D et al.	—	2023	→
Somatosensory innervation of adipose tissues.	Wang Y et al.	—	2023	→
Somatosensory neurons express specific sets of lincRNAs, and lincRNA CLAP promotes itch sensation in mice.	Wang B et al.	—	2023	→
Somatosensory neuron types and their neural networks as revealed via single-cell transcriptomics.	Wang K et al.	—	2023	→
SPACEL: deep learning-based characterization of spatial transcriptome architectures.	Xu H et al.	—	2023	→
Spatial atlas of the mouse central nervous system at molecular resolution.	Shi H et al.	—	2023	→
Spatial cell-type enrichment predicts mouse brain connectivity.	Sun S et al.	—	2023	→
Spatial epigenome-transcriptome co-profiling of mammalian tissues.	Zhang D et al.	—	2023	→
Spatially resolved single-cell translatomics at molecular resolution.	Zeng H et al.	—	2023	→
Spatial Transcriptomics: Technical Aspects of Recent Developments and Their Applications in Neuroscience and Cancer Research.	Park HE et al.	—	2023	→
Specialized astrocytes mediate glutamatergic gliotransmission in the CNS.	de Ceglia R et al.	—	2023	→
Spinal cords: Symphonies of interneurons across species.	Wilson AC et al.	—	2023	→
Spinal Interneurons: Diversity and Connectivity in Motor Control.	Sengupta M et al.	—	2023	→
Spiny projection neurons exhibit transcriptional signatures within subregions of the dorsal striatum.	Roman KM et al.	—	2023	→
STEEL enables high-resolution delineation of spatiotemporal transcriptomic data.	Chen Y et al.	—	2023	→
Stepwise emergence of the neuronal gene expression program in early animal evolution.	Najle SR et al.	—	2023	→
stVAE deconvolves cell-type composition in large-scale cellular resolution spatial transcriptomics.	Li C et al.	—	2023	→
Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain: an update.	Berta T et al.	—	2023	→
The benefits and pitfalls of machine learning for biomarker discovery.	Ng S et al.	—	2023	→
The Co-Expression Pattern of Calcium-Binding Proteins with γ-Aminobutyric Acid and Glutamate Transporters in the Amygdala of the Guinea Pig: Evidence for Glutamatergic Subpopulations.	Kalinowski D et al.	—	2023	→
The Delta-Opioid Receptor Bidirectionally Modulates Itch.	Smith KM et al.	—	2023	→
The enteric nervous system.	Sharkey KA et al.	—	2023	→
The glycine receptor alpha 3 subunit mRNA expression shows sex-dependent differences in the adult mouse brain.	Ceder MM et al.	—	2023	→
The histamine H3 receptor modulates dopamine D2 receptor-dependent signaling pathways and mouse behaviors.	Xu J et al.	—	2023	→
The influence of Nav1.9 channels on intestinal hyperpathia and dysmotility.	Zhao C et al.	—	2023	→
The molecular cytoarchitecture of the adult mouse brain.	Langlieb J et al.	—	2023	→
The parenting hub of the hypothalamus is a focus of imprinted gene action.	Higgs MJ et al.	—	2023	→
The peripheral nervous system.	Murtazina A et al.	—	2023	→
The proteomic landscape of synaptic diversity across brain regions and cell types.	van Oostrum M et al.	—	2023	→
The Similar and Distinct Roles of Satellite Glial Cells and Spinal Astrocytes in Neuropathic Pain.	McGinnis A et al.	—	2023	→
The spatial landscape of gene expression isoforms in tissue sections.	Lebrigand K et al.	—	2023	→
The T-type calcium channel Ca V 3.2 regulates bladder afferent responses to mechanical stimuli.	Grundy L et al.	—	2023	→
The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions.	Fan Z et al.	—	2023	→
Time-resolved single-cell RNAseq profiling identifies a novel <i>Fabp5</i><sup>+</sup> subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury.	Hamel R et al.	—	2023	→
TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice.	Wang Y et al.	—	2023	→
Tracking cell-type-specific temporal dynamics in human and mouse brains.	Lu Z et al.	—	2023	→
Transcriptional diversity in specific synaptic gene sets discriminates cortical neuronal identity.	Roig Adam A et al.	—	2023	→
Transcriptomic cytoarchitecture reveals principles of human neocortex organization.	Jorstad NL et al.	—	2023	→
Transcriptomic diversity of cell types across the adult human brain.	Siletti K et al.	—	2023	→
Transcriptomics of Hirschsprung disease patient-derived enteric neural crest cells reveals a role for oxidative phosphorylation.	Li Z et al.	—	2023	→
Two distinct molecular faces of preeclampsia revealed by single-cell transcriptomics.	Admati I et al.	—	2023	→
Wnt signal-dependent antero-posterior specification of early-stage CNS primordia modeled in EpiSC-derived neural stem cells.	Nakamura K et al.	—	2023	→
Yin Yang 1 controls cerebellar astrocyte maturation.	Mockenhaupt K et al.	—	2023	→
Activated astrocytes attenuate neocortical seizures in rodent models through driving Na<sup>+</sup>-K<sup>+</sup>-ATPase.	Zhao J et al.	—	2022	→
A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry.	Keeler AB et al.	—	2022	→
Advances in Single-Cell Sequencing Technology and Its Application in Poultry Science.	Liu Y et al.	—	2022	→
A method to estimate the cellular composition of the mouse brain from heterogeneous datasets.	Rodarie D et al.	—	2022	→
Apamin structure and pharmacology revisited.	Kuzmenkov AI et al.	—	2022	→
AQP4, Astrogenesis, and Hydrocephalus: A New Neurological Perspective.	Castañeyra-Ruiz L et al.	—	2022	→
Artificial pore blocker acts specifically on voltage-gated potassium channel isoform K<sub>V</sub>1.6.	Gigolaev AM et al.	—	2022	→
Astrocyte development in the cerebral cortex: Complexity of their origin, genesis, and maturation.	Clavreul S et al.	—	2022	→
Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes.	Mazumder AG et al.	—	2022	→
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice.	Calls A et al.	—	2022	→
A unified computational framework for single-cell data integration with optimal transport.	Cao K et al.	—	2022	→
Automatic Cell Type Annotation Using Marker Genes for Single-Cell RNA Sequencing Data.	Chen Y et al.	—	2022	→
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies.	Zhang Y et al.	—	2022	→
Comprehensive Behavioral Analysis of Opsin 3 (Encephalopsin)-Deficient Mice Identifies Role in Modulation of Acoustic Startle Reflex.	Upton BA et al.	—	2022	→
Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment.	Szadai Z et al.	—	2022	→
Data management strategy for a collaborative research center.	Mittal D et al.	—	2022	→
dcHiC detects differential compartments across multiple Hi-C datasets.	Chakraborty A et al.	—	2022	→
Deep proteome profiling reveals signatures of age and sex differences in paw skin and sciatic nerve of naïve mice.	Xian F et al.	—	2022	→
Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features.	Karpf J et al.	—	2022	→
Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled <i>NEUROG2</i> overexpression.	Plumbly W et al.	—	2022	→
Developmental control of noradrenergic system by SLITRK1 and its implications in the pathophysiology of neuropsychiatric disorders.	Hatayama M et al.	—	2022	→
Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment.	Dumrongprechachan V et al.	—	2022	→
Fibroblast growth factor homologous factor 2 attenuates excitability of DRG neurons.	Effraim PR et al.	—	2022	→
From multitude to singularity: An up-to-date overview of scRNA-seq data generation and analysis.	Carangelo G et al.	—	2022	→
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection.	Zhang W et al.	—	2022	→
Highly sensitive single-cell chromatin accessibility assay and transcriptome coassay with METATAC.	Wu H et al.	—	2022	→
Human Stem Cell-Derived TRPV1-Positive Sensory Neurons: A New Tool to Study Mechanisms of Sensitization.	Schrenk-Siemens K et al.	—	2022	→
HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus.	Steuernagel L et al.	—	2022	→
<i>DeepVelo</i>: Single-cell transcriptomic deep velocity field learning with neural ordinary differential equations.	Chen Z et al.	—	2022	→
Identification of visual cortex cell types and species differences using single-cell RNA sequencing.	Wei JR et al.	—	2022	→
<i>In vitro</i> models for investigating itch.	Mießner H et al.	—	2022	→
In situ cell-type-specific cell-surface proteomic profiling in mice.	Shuster SA et al.	—	2022	→
Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability.	Feleke R et al.	—	2022	→
Interactions between nociceptor sensory neurons and microbial pathogens in pain.	Staurengo-Ferrari L et al.	—	2022	→
Local production of corticotropin-releasing hormone in prefrontal cortex modulates male-specific novelty exploration.	Riad MH et al.	—	2022	→
Mechanism and effects of STING-IFN-I pathway on nociception: A narrative review.	Yang J et al.	—	2022	→
Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects.	Verkest C et al.	—	2022	→
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex.	Ma S et al.	—	2022	→
Multi-level cellular and functional annotation of single-cell transcriptomes using scPipeline.	Mikolajewicz N et al.	—	2022	→
Multimodal Single-Cell Translation and Alignment with Semi-Supervised Learning.	Zhang R et al.	—	2022	→
Nav1.7 is required for normal C-low threshold mechanoreceptor function in humans and mice.	Middleton SJ et al.	—	2022	→
Neonatal antibiotics have long term sex-dependent effects on the enteric nervous system.	Poon SSB et al.	—	2022	→
Neurexins and their ligands at inhibitory synapses.	Boxer EE et al.	—	2022	→
Neuronally expressed PDL1, not PD1, suppresses acute nociception.	Meerschaert KA et al.	—	2022	→
Neurons and glial cells acquire a senescent signature after repeated mild traumatic brain injury in a sex-dependent manner.	Schwab N et al.	—	2022	→
Neuropathology of classic myotonic dystrophy type 1 is characterized by both early initiation of primary age-related tauopathy of the hippocampus and unique 3-repeat tauopathy of the brainstem.	Hamasaki H et al.	—	2022	→
Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces.	Tsou AM et al.	—	2022	→
Novel localization of folate transport systems in the murine central nervous system.	Sangha V et al.	—	2022	→
Oxidative Stress-Induced HMGB1 Translocation in Myenteric Neurons Contributes to Neuropathy in Colitis.	Stavely R et al.	—	2022	→
Parabrachial nucleus astrocytes regulate wakefulness and isoflurane anesthesia in mice.	Liu PC et al.	—	2022	→
Patchouli alcohol improved diarrhea-predominant irritable bowel syndrome by regulating excitatory neurotransmission in the myenteric plexus of rats.	Chen W et al.	—	2022	→
Plasma membrane phospholipid phosphatase-related proteins as pleiotropic regulators of neuron growth and excitability.	Fuchs J et al.	—	2022	→
Polony gels enable amplifiable DNA stamping and spatial transcriptomics of chronic pain.	Fu X et al.	—	2022	→
Recent advances in deciphering oligodendrocyte heterogeneity with single-cell transcriptomics.	Valihrach L et al.	—	2022	→
Research progress of single-cell transcriptome sequencing in autoimmune diseases and autoinflammatory disease: A review.	Zeng L et al.	—	2022	→
scGWAS: landscape of trait-cell type associations by integrating single-cell transcriptomics-wide and genome-wide association studies.	Jia P et al.	—	2022	→
scRNA-sequencing reveals subtype-specific transcriptomic perturbations in DRG neurons of <i>Pirt<sup>EGFPf</sup></i> mice in neuropathic pain condition.	Zhang C et al.	—	2022	→
Silk scaffolding drives self-assembly of functional and mature human brain organoids.	Sozzi E et al.	—	2022	→
Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons.	Matson KJE et al.	—	2022	→
Single-cell RNA sequencing reveals dysregulation of spinal cord cell types in a severe spinal muscular atrophy mouse model.	Sun J et al.	—	2022	→
Single-cell technologies: From research to application.	Wen L et al.	—	2022	→
Single nucleus transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine intake.	Reiner BC et al.	—	2022	→
Spatial-ID: a cell typing method for spatially resolved transcriptomics via transfer learning and spatial embedding.	Shen R et al.	—	2022	→
Spatially aware dimension reduction for spatial transcriptomics.	Shang L et al.	—	2022	→
SPROUT: spectral sparsification helps restore the spatial structure at single-cell resolution.	Wang J et al.	—	2022	→
Systematic investigation of imprinted gene expression and enrichment in the mouse brain explored at single-cell resolution.	Higgs MJ et al.	—	2022	→
Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis.	Mukhtar T et al.	—	2022	→
The Enteric Glia and Its Modulation by the Endocannabinoid System, a New Target for Cannabinoid-Based Nutraceuticals?	López-Gómez L et al.	—	2022	→
The industrial genomic revolution: A new era in neuroimmunology.	Shalita R et al.	—	2022	→
The neurons that restore walking after paralysis.	Kathe C et al.	—	2022	→
Toward a granular molecular-anatomic map of the blood vasculature - single-cell RNA sequencing makes the leap.	Betsholtz C	—	2022	→
Trans-cardiac perfusion of neonatal mice and immunofluorescence of the whole body as a method to study nervous system development.	Pérez Arévalo A et al.	—	2022	→
Transcriptomic analysis of paternal behaviors in prairie voles.	Duclot F et al.	—	2022	→
Transcriptomic and proteomic profiling of Na<sub>V</sub>1.8-expressing mouse nociceptors.	Schmidt M et al.	—	2022	→
Transcriptomic architecture of nuclei in the marmoset CNS.	Lin JP et al.	—	2022	→
Understanding the aging hypothalamus, one cell at a time.	Hajdarovic KH et al.	—	2022	→
X-box binding protein 1 as a key modulator in "healing endothelial cells", a novel EC phenotype promoting angiogenesis after MCAO.	Chen Z et al.	—	2022	→