those present in parietal lobe and cerebellum we found that ∼25% of both TS and OCD heritability was accounted for by parietal eQTLs, ∼10% of both TS and OCD heritability was accounted for by eQTLs found in both tissues, and that cerebellar eQTLs again accounted for more heritability (20%) in OCD than in TS (9%) (Table S8, Figure S9). We then tested a final model in which brain eQTLs from cerebellum and parietal tissues were combined into a single “brain-only” partition, and included in the same joint analysis with muscle eQTLs, eQTL found in both brain and muscle, and a non-eQTL partition. In this model, brain eQTLs accounted for 33% (h2 = 0.16, se = 0.10, p = 0.06) of the total TS heritability and 59% (h2 = 0.19, se = 0.08, p = 0.009) of the total heritability for OCD. Skeletal muscle eQTLs accounted for 25% (h2 = 0.12; se = 0.10; p = 0.1) of the total TS heritability and 25% (h2 = 0.08; se = 0.09; p = 0.2) of the total heritability for OCD. The overlapping set of eQTLs identified in both muscle and brain accounted for 8% heritability in TS (h2 = 0.04; se =
