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Chunk #25 — Results — Analysis by Annotation Classification

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Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.
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In the analysis of directly genotyped data, we found that genic variants accounted for 53% (0.30, se = 0.07; p = 0.008) of the total TS heritability and 40% (h2 = 0.15, se = 0.06, p = 0.003) of the total OCD heritability (Table S7). In the analysis of imputed data, parietal lobe eQTLs accounted for 28% (h2 = 0.13, se = 0.08; p = 0.03) of the total TS heritability and 29% (h2 = 0.09, se = 0.06; p = 0.1) of the total OCD heritability. Cerebellar eQTLs accounted for 35% (h2 = 0.11, se = 0.06; p = 0.02) of the total OCD heritability but only 19% (h2 = 0.09, se = 0.07; p = 0.1) of the total TS heritability ( Table 3 ). When the brain eQTLs were further subdivided into parietal “only”, cerebellum “only” and those present in parietal lobe and cerebellum we found that ∼25% of both TS and OCD heritability was accounted for by parietal eQTLs, ∼10% of both TS and OCD heritability was accounted for by eQTLs found in both tissues, and