We identified a significant difference between TS and OCD in the proportion of heritability accounted for by variants with MAF<0.05 ( Table 2 , Figure 3 ). This result was observed in both the directly genotyped data and imputed data. Using the directly genotyped data, TS SNPs with MAF<0.05 (N = 20,316; 5.3% of all directly genotyped SNPs) represented 21% (0.13, se = 0.04) of the total calculated heritability, while OCD SNPs with MAF<0.05 (N = 19,605; 5.2% of all directly genotyped SNPs) represented 0% (0.000001, se = 0.01) of the total calculated heritability. Similar results were observed using the imputed data, with approximately 30% of the total heritability of TS captured by variants with MAF<0.05 (N = 2,243,744; 30% of all imputed SNPs) and 0% of the total heritability of OCD captured by variants with MAF<0.05 (2,357,568; 30% of all imputed SNPs).
