Here, we discuss biological and experimental challenges associated with hiPSC derivation and review applications of hiPSC derived neuronal cells to model neurodevelopmental diseases. We begin by discussing the current state of our understanding of neurodevelopmental disorders as derived from neuroimaging, genetic, and pathological studies. We then discuss the shortcomings of such studies and the power hiPSCs possess to overcome them and advance our understanding. Following this we discuss the specifics and mechanics behind building hiPSC model systems and end with a comprehensive overview of existing hiPSC models of neurodevelopmental disorders.
