Chunk #13 — 2. Materials and Methods — 2.7. Genomic Data and Polygenic Risk Scores (PRS)

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Predicting Alcohol-Related Memory Problems in Older Adults: A Machine Learning Study with Multi-Domain Features.

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We created PRS using PRS-CSx [63,64,65,66,67], which is a recent, validated method for cross-ancestry polygenic prediction [68]. The PRS-CSx computation method is detailed elsewhere (https://github.com/getian107/PRScsx, accessed on 1 December 2021) and is also briefly described in Section S1.7 of the Supplementary Materials.