a Drosophila RNAi screen for regulators of the neuroblast fate revealed that knockdown of Brahma, Moira and Osa (homologs of BRM, BAF47 and BAF250, respectively) results in the generation of extra neuroblasts at the expense of differentiated neurons (Neumüller et al., 2011); Osa was subsequently shown to control the progression of neural differentiation program and prevent tumorigenesis by regulating the number of progenitor divisions (Eroglu et al., 2014). The prevalence of BAF250A/B mutations prompts a greater understanding of how they function in the mammalian CNS.
