The GWS association locus on chromosome 4 from the GENOA EA analysis (rs28386916-A, beta = 0.17, p = 9.04 × 10–9) was not included in the gSEM analysis as it was absent from the MVP and PH GWAS. However, several variants in high LD (D’ > 0.6) with it were not significant in the gSEM analysis (minimum p-value for rs11943738—p = 0.001, beta = 0.057, and SE = 0.017, Supplementary Table 10).
