Intergenic variant rs13333582 on chromosome 16 was also GWS (Supplementary Fig. 12), with the minor C allele decreasing risk of OA (beta = − 0.22). While rs13333582 passed QC, (MAF = 0.04, INFO > 0.8, for all cohorts), variants in strong LD showed weaker evidence for association (e.g., rs921982 r2 = 0.87, p = 2.25 × 10–3). In addition, rs13333582 was not significant in the GENOA AA analysis (p = 0.28), and the direction of effect was opposite of that observed in the gSEM EA analysis.
