Taking advantage of the comprehensive COGA data provides unique opportunities for innovation, such as conducting genome‐wide survival analyses for onset of alcohol dependence in extended pedigrees using Cox proportional hazards with robust variance estimators 90 and admixture mapping of AUD and subjective ratings of ethanol sensitivity in African ancestry families 91 using rvtests. 92 COGA led some of the earliest GWAS of AUD, 72 , 73 which were initially conducted in the case–control sample (N = 1399). As genotyping of the sample expanded, GWAS were carried out on several relevant phenotypes: AUD diagnosis, 61 AUD severity (indexed by criterion counts 61 ), individual AUD criteria, 61 subjective response to ethanol, 93 comorbid conditions such as any drug use disorder, 94 externalizing disorders, 95 theta band event‐related oscillations, and interhemispheric theta EEG coherence 75 , 96 , 97 (see, Table 2 for review of findings).
