The GeneChip® Rat Genome U34 Set provides gene expression data for more than 24,000 known genes and EST clusters for comprehensive coverage of the rat genome. The two brain regions were evaluated separately. 3-way ANOVA revealed 542 genes differentially expressed at a p<0.05 in either caudate putamen or amygdala or both brain regions of alcohol preferring P, HAD, and AA rats after one year of ethanol consumption. A detailed description of the ‘rodent candidate gene’ strategy for selection of markers for the follow-up study is given in paragraph ‘Integration of animal data into the human study’.
