5403 European ancestry controls were derived primarily from cohorts of previously genotyped, unselected population controls (Supplementary Methods, Table S1). These included 3212 controls from the Illumina Genotype Control Database genotyped on the Illumina HumanHap550v1/v3 platforms (www.Illumina.com, Illumina, San Diego, CA, USA), 1288 controls from the Studies of Addiction: Genetics and Environment (SAGE) cohort 17-19 genotyped on the Illumina HumanHap1Mv1_C, and 653 Dutch ancestry controls genotyped on the Illumina HumanHap550v120. An additional 298 German and Dutch EU controls were genotyped simultaneously with the TS case samples, including 48 duplicates from the Dutch 550v1 control cohort, to facilitate cross-platform and cross-facility comparisons.
