297 FC and 380 ANT ancestry-matched controls were collected in parallel with their respective cases (Supplementary Methods). ANT controls were used for analysis of both ANT and CVCR cases given their shared ancestry.21-22 All participants 18 years of age and older gave informed consent. Individuals under 18 years of age gave assent after a parent signed a consent form on their behalf. The research project was approved by the Ethics Committees of each participating site.
