Genotyping of 908 of the 1252 EU cases and all population-isolate cases (AJ, FC, ANT, CVCR), as well as 298 EU and all FC and ANT controls, was conducted on the Illumina Human610-Quadv1_B SNP array (Illumina, San Diego, CA, USA) at the Broad Institute of Harvard and MIT (Cambridge, MA, USA) in two batches using standard protocols. Samples were randomized across plates and batches both by originating site and case-control status. Genotype calling was performed using BeadStudio (Illumina, San Diego, CA). 432 EU cases were genotyped on the Illumina HumanCNV370-Duo_v1 at the Yale Center for Genome Analysis (New Haven, CT, USA), including 88 duplicate EU samples overlapping with those genotyped on the 610-Quad platform to allow for cross-platform checks of concordance.
