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Chunk #9 — METHODS — Childhood studies

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Genetic variation in LIN28B is associated with the timing of puberty.
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We analyzed 8,859 ALSPAC children (4,588 boys and 4,271 girls) to examine the association between rs312726 genotype and timing of adolescent growth (between ages 7 to 11 years), pubic hair stage in boys and breast development in girls. Data on pubertal development (voice breaking status and pubic hair stage) at age 15 years were available for NSHD men (N = 1,026). We analyzed 1,964 individuals from the Danish and Estonian cohorts of the cross-sectional European Youth Heart Study (EYHS) to determine the association between rs312726 and pubertal stage.