Associations between SNPs and age at menarche (women only), height, weight, BMI, waist circumference and percentage body fat were conducted in men and women separately using linear regression assuming an additive genetic model and adjusting for age. In ALSPAC mothers, multiple regression models were performed including both rs314276 and rs314277 to identify the independent effects of each SNP on age at menarche and height. Summary statistics were meta-analyzed with the initial GWA study sets using the inverse variance–weighted method. Analyses were performed using Stata/s.e.m. 9.2 for Windows (StataCorp).
