Genotyping of rs314276 and rs314277 was conducted using TaqMan (Applied Biosystems) (EPIC and NSHD) or by KBiosciences (ALSPAC). Genotype data from B58C was obtained using an Affymetrix GeneChip Human Mapping 500K Array. Genotype frequencies were in Hardy-Weinberg equilibrium (all P > 0.2), and call rates were all >90%.
