Our planned age 45 assessment will begin in 2017 and finish toward the end of 2018. We plan to gather new data to augment the extensive data already held. We will test a number of hypotheses aimed at better understanding the complex process of ageing. We will also expand our data collection efforts to capitalise on data already held about conditions associated with very high rates of disability [117], e.g. musculoskeletal problems and chronic kidney disease.