Our study did not reveal any statistically significant association between alcohol dependence or alcohol abuse and A118G polymorphism (P > 0.05). The finding is in line with a number of previous studies (Bergen et al., 1997; Sander et al., 1998; Gelernter et al., 1999; Kim et al., 2004a; Loh el et al., 2004; Zhang et al., 2006). While there have been several findings suggesting an association, the results have been conflicting. A few studies have reported either a significant association (Bart et al., 2005; Nishizawa et al., 2006) or a non-significant trend (Rommelspacher et al., 2001; Kim et al., 2004b) between the G allele and alcohol dependence. In contrast, some studies have reported a significant association between the A allele and alcohol dependence (Town et al., 1999; Schinka et al., 2002; Du and Wan, 2009; Koller et al., 2012). Since the majority of the results pointing towards an association between the A118G polymorphism and alcohol dependence do not reach statistical significance and the few significant studies report conflicting results with respect to the ‘at-risk’ allele, the evidence regarding the link
