In order to clarify the role of OPRM1 polymorphism in alcohol use disorders, we investigated the possible association of OPRM1 A118G polymorphism on alcohol consumption and on susceptibility to alcohol dependence in three large population-based study populations. Our study populations included two cohorts of sizes 2360 and 1384, which were analyzed with respect to alcohol consumption as well as a diagnosis-based population sample of 503 individuals with alcohol dependence or alcohol abuse diagnosis and their 506 age- and sex-matched controls, which were drawn from a nationwide study cohort. To our knowledge, our study is the first cohort-based study investigating the association between OPRM1 A118G polymorphism and alcohol use disorders or alcohol consumption.
