The role of OPRM1 A118G (Asn40Asp) polymorphism in susceptibility to alcohol use disorders and alcohol consumption has remained controversial in prior research. The polymorphism has in several studies been shown to affect alcohol sensitivity and consumption in animal models and in humans. Furthermore, μ-opioid antagonists have reduced alcohol consumption in both experimental setting and in the clinical use. However, molecular epidemiological studies investigating the association between the polymorphism and alcohol dependence have produced inconsistent results.
