statistically significant results were obtained in the Health 2000 study population when the consumption was analyzed separately among controls (n = 504) and individuals with alcohol dependence/abuse diagnosis (n = 502) (data not shown). Table 3.Sex- and age-adjusted associations between OPRM1 A118G polymorphism and alcohol consumption-related phenotypes in the three Finnish cohortsPhenotypenBetaa95% CIP-valueHealth 2000Average intake of ethanol in EtOH gram per kilogram per week during last yearb1006c0.03−0.080.130.63FINRISKAUDITb23500.02−0.040.070.54QFb2319−0.04−0.110.030.24TLFBb2318−0.02−0.120.080.68HBCSAlcohol use frequency1384−0.03−0.130.070.52Results obtained by using additive genetic model.AUDIT, Alcohol Use Disorders Identification Test; QF, quantity-frequency score; TLFB, Timeline Follow-back.aUnstandardized betas were derived from the multiple regression analyses.bLog-transformed values.cConsumption data available from 504 controls and 502 individuals with alcohol use disorder. Data adjusted for diagnosis.
