The association with OPRM1 polymorphism and alcohol consumption was analyzed in three different populations by using the data available from each group. For Health 2000 study population (n = 1006), the data was analyzed with respect to the average intake of ethanol in pure ethanol gram per weight kilogram per week during the previous year as calculated from the Health 2000 interview data. For the FINRISK study population (n = 2360) TLFB, AUDIT and QF-based information was used, whereas with respect to the HBCS study population (n = 1384) the analyses were based on drinking frequency information obtained from interview data. The results are shown in Table 3. No statistically significant associations were observed in any of the three cohorts (P-values >0.24) using either an additive genetic model (Table 3) or dominant or recessive models (data not shown). Also, no statistically significant results were obtained in the Health 2000 study population when the consumption was analyzed separately among controls (n = 504) and individuals with alcohol dependence/abuse diagnosis (n = 502) (data not shown). Table 3.Sex- and age-adjusted associations between
