The association between OPRM1 A118G (Asn40Asp, rs1799971) polymorphism and alcohol use disorders was analyzed in a population-based sample consisting of genotyping results from 503 individuals with a DSM-IV-based diagnosis of alcohol dependence or alcohol abuse and their 506 age- and sex-matched controls. No statistically significant associations were observed (Table 2, additive model; data not shown for recessive and dominant models). The prevalence of the 118 G allele was 21.2% among the controls and 20.3% among individuals with alcohol use disorders and the frequencies of AA, AG and GG genotypes were 63.2%, 31.0 and 5.7% among the controls and 64.6, 30.2 and 5.2% among the individuals with alcohol use disorders, respectively. Table 2.Sex- and age-adjusted associations between OPRM1 A118G polymorphism and DSM-IV-based alcohol use disorder diagnosisPhenotypenORa95% CIP-valueHealth 2000Alcohol dependence or alcohol abuse1009b0.950.771.170.60Alcohol dependence915c0.950.761.180.63Alcohol abuse592d0.940.631.390.75Results obtained by using additive genetic model.aOdds Ratios (ORs) were derived from the multiple logistic regression analyses.b506 controls + 503 individuals with alcohol dependence and/or alcohol abuse diagnosis (including 8 individuals with alcohol abuse diagnosis but no information about dependence diagnosis).c409 individuals with alcohol dependence + 506 controls.d86 individuals with alcohol abuse + 506 controls
