The frequency of the 118G (Asp40) allele was relatively similar in all three populations: 20.8% in Health 2000, 18.6% in FINRISK and 19.0% in HBCS (Table 1). The mean allele frequency for the G variant in all three populations combined was 19.2%. Expressed in terms of individuals having a particular genotype, of the total 4762 individuals tested, 65.4% were A/A, 30.8% were A/G and 3.7% were G/G. The genotypic distribution did not significantly differ from the expected Hardy–Weinberg distribution in any of the population samples (P-values >0.12).
