with the finding that chronicity increases risk. We are likely underestimating the effect of chronicity of exposure since we are limited to detecting severe manifestations (that is, repeated parental EB registrations across time frames). A third possibility is that the risk conferred is primarily genetic, as that would not change across development. If this were the case, we could interpret the greater risk conferred by sustained exposure to be indicative of severity: Perhaps the more severely affected parents in turn pass on higher genetic liability to their offspring.
