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Chunk #20 — Results — ROI results

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Disrupted functional connectivity with dopaminergic midbrain in cocaine abusers.
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CM and BOLD signals in the thalamus were significantly correlated for control subjects (R = 0.61; P = 0.003; Fig. 7A) but not for cocaine subjects. CM signals in the thalamus were correlated negatively with the number of years of cocaine use in the cocaine subjects (R = −0.64; P = 0.002; Fig. 7B). BOLD and CM signals in CER and MDTHA did not show statistically significant correlations with self-reported time since last use of cocaine. However, CM (but not BOLD) signals in rACC were significantly correlated with self-reported time since last use of cocaine (Pc = 0.008, Bonferroni corrected for multiple comparisons; Z = 2.8).