be mimicked by pharmacological blockade of PKA in ethanol-naïve-preferring rats or non-preferring rats (60, 84). Thus, anxiety-induced downregulation of CREB function in the AMG may constitute a critical neuroadaptation central to the development and maintenance of alcohol dependence. As regards, dysregulation of the PFC associated with a functional disconnection between the PFC and AMG central nucleus during abstinence and renewed access to alcohol has been implicated in long-lasting cognitive impairment and excessive alcohol drinking in rats (46).
