Chunk #18 — Molecular Mechanisms Underlying Anxiety-Like and Alcohol-Drinking Behaviors: The Role of cAMP–PKA–CREB Cascade

Source: Behavioral Neuroadaptation to Alcohol: From Glucocorticoids to Histone Acetylation.
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Clinical evidence from alcohol-dependent patients also indicates that acute and protracted withdrawal/abstinence is strongly associated with depressive-like behaviors, such as anhedonia.