Windrem et al., 2014) and SCZ glial chimeric mice have broad behavioral and sleep abnormalities (Windrem et al., 2017). This approach is extremely intriguing, we speculate that human glial or neurons derived from iPS cells derived from subjects with AUDs, when grafted into mouse brains which permits longer term chronic exposure to alcohol in vivo, allows behavioral and metabolic assessments of the animals as well as morphological, functional and genomic evaluations of grafted human neurons under the influence of alcohol. This potentially can generate a novel hypothesis for the elucidation of the pathophysiology as well as the etiology of AUDs.
