Utilizing stem cell biology to model AUDs is still in its nascent stage however it holds great potential to uncover the genetic, molecular, cellular and circuitry mechanisms underlying the etiology and pathophysiology of AUDs. Recent developments modeling human neuropsychiatric or neurological disorders provided guidelines on how we can potentially harness this fascinating technology to devise effective individualized therapeutics or preventions for those who suffer or are susceptible to suffer from AUDs.